Barone Frank, Bashey Sameer, Woodin Jr. Frederick W.
J Drugs Dermatol. 2019 Mar 1;18(3):290-295.
Background: Topical skin care products use various technologies to promote skin repair. Growth factors of human, animal, and plant-derived origins have clinically demonstrated the ability to repair skin by promoting collagen, elastin, and glycosaminoglycan (GAG) production to reconstruct and reinforce skin’s extracellular matrix (ECM). Human skin cells respond to instructions from highly specialized proteins or hormones referred to as growth factors. These growth factors initiate cellular communication that instigates cellular replication, production, or proliferation. The production of elastin and collagen dermal connective fibers slows, and, with age, the regenerative rates of GAGs become delayed. These biological issues can be exacerbated by extrinsic factors such as sun exposure, pollutants, and various other factors. Growth factor-based products have become important topical treatment modalities for addressing signs of skin aging such as fine lines, deep wrinkles, dryness, laxity, and textural irregularities. Objective: The aim of a 12-week clinical trial of a growth factor composition was to assess its effectiveness at restoring skin health through dermal and epidermal restructuring of aged skin. Results: Data from expert grading, and from corneometer and cutometer evaluations, as well as 2D and 3D image analysis, reflected significant improvements in facial skin appearance, firmness, elasticity, and hydration. Elements that improved most dramatically in investigators’ assessments included radiance, firmness, tactile elasticity, textural smoothness, overall appearance, and crow’s feet. Ultrasound imaging showed continual increases in dermal and epidermal restructuring throughout the study duration. Subject assessments reflected positive product tolerability and positive perception across a broad range of efficacy attributes through 12 weeks of usage. Conclusion: The results verified the ability of a multi-modal plant and enzymatically derived growth factor-based product to achieve skin rejuvenation improvements by stimulating dermal ECM and fibrous tissue regeneration to reduce fine lines and coarse wrinkles, and improve skin firmness and elasticity, while restoring skin to a properly hydrated state. J Drugs Dermatol. 2019;18(3):290-295.
局部皮肤护理产品采用多种技术来促进皮肤修复。人源、动物源和植物源的生长因子在临床上已证明能够通过促进胶原蛋白、弹性蛋白和糖胺聚糖（GAG）的生成来修复皮肤，从而重建和强化皮肤的细胞外基质（ECM）。人类皮肤细胞会对被称为生长因子的高度专业化蛋白质或激素发出的指令做出反应。这些生长因子引发细胞间通讯，从而促使细胞复制、生成或增殖。随着年龄增长，弹性蛋白和胶原蛋白真皮结缔纤维的生成速度减慢，GAGs的再生速度也会延迟。这些生物学问题会因诸如日晒、污染物和各种其他因素等外在因素而加剧。基于生长因子的产品已成为解决皮肤衰老迹象（如细纹、深皱纹、干燥、松弛和质地不均）的重要局部治疗方式。目的：一项关于生长因子组合物的12周临床试验旨在评估其通过对老化皮肤进行真皮和表皮重组来恢复皮肤健康的有效性。结果：来自专家评分、角质层水合测定仪和皮肤弹性测定仪评估以及二维和三维图像分析的数据表明，面部皮肤外观、紧致度、弹性和水合作用有显著改善。在研究者的评估中改善最为显著的因素包括光泽度、紧致度、触觉弹性、质地光滑度、整体外观和鱼尾纹。超声成像显示在整个研究期间真皮和表皮重组持续增加。受试者评估反映出在12周的使用过程中，产品具有良好的耐受性，并且在广泛的功效属性方面都有积极的评价。结论：结果证实了一种基于多模式植物和酶促衍生生长因子的产品能够通过刺激真皮ECM和纤维组织再生来实现皮肤年轻化改善，减少细纹和粗皱纹，提高皮肤紧致度和弹性，同时使皮肤恢复到适当的水合状态。《药物皮肤病学杂志》。2019年；18（3）：290 - 295。
