Rodan + Fields, San Francisco, CA, USA.
Department of Dermatology, Stanford University, Stanford, CA, USA.
J Cosmet Dermatol. 2020 May;19(5):1246-1253. doi: 10.1111/jocd.13136. Epub 2019 Sep 9.
Hydration and moisturization both impact skin quality, directly reflecting its appearance. Signs and onset of dehydration-related skin aging are region-specific and require tailored treatment to be effective.
To test the hydrating effects of formulas containing a novel 3-dimensional 3-polymer interpenetrating network (3D3P-IPN) to deliver humectants and actives to specific body sites.
Two clinical studies were conducted focused on the skin under eyes and body (arms/legs). Healthy women ages 25-65 (eyes) or 35-65 (body) with mild to moderate dry and aged skin were enrolled. Study product containing the 3D3P-IPN and tailored actives was applied twice daily for 8 weeks on the periorbital area and for 4 weeks on the body. Changes in skin attributes were measured by biophysical instrumentation for hydration, dark circles, skin color, elasticity and transepidermal water loss, and by clinical grading and subject self-assessment.
Significant improvements in hydration and skin smoothing were demonstrated in both studies. In the periorbital region, actives and humectants delivered by the 3D3P-IPN also led to significant improvements in dark circles, fine lines/crow's feet, puffiness, restoring radiance, and overall younger-looking appearance. On the arms and legs, there were significant reductions in crepiness and dullness. The arms and legs also had improvements in tactile and visual skin texture, radiance, and general healthy look. Improvements were immediate and persisted through the end of both studies.
The 3D3P-IPN provides immediate and long-lasting improvements in skin hydration and overall healthy appearance regardless of the targeted application site.
水合作用和保湿作用都会影响皮肤质量，直接反映其外观。与脱水相关的皮肤老化的迹象和发病部位具有区域特异性，需要进行针对性的治疗才能有效。
测试含有新型 3 维 3 聚合物互穿网络（3D3P-IPN）的配方的保湿效果，以便将保湿剂和活性剂输送到特定的身体部位。
进行了两项针对眼部和身体（手臂/腿部）皮肤的临床研究。纳入年龄在 25-65 岁（眼部）或 35-65 岁（身体）之间、皮肤干燥且老化程度为轻度至中度的健康女性。在眼部周围区域每天使用两次含有 3D3P-IPN 和针对性活性剂的研究产品，在身体上使用 4 周。通过生物物理仪器测量皮肤属性的变化，包括水分、黑眼圈、肤色、弹性和经表皮水分流失，以及通过临床评分和受试者自我评估。
两项研究均显示皮肤水分和皮肤光滑度显著改善。在眼周区域，3D3P-IPN 输送的活性剂和保湿剂还显著改善了黑眼圈、细纹/鱼尾纹、浮肿、恢复光泽和整体年轻外观。在手臂和腿部，皮肤的粗糙感和无光泽感显著减少。手臂和腿部的触觉和视觉皮肤纹理、光泽度和整体健康外观也得到改善。改善效果是即时的，并持续到两项研究结束。
无论目标应用部位如何，3D3P-IPN 均可立即并持久地改善皮肤水分和整体健康外观。
