微小RNA在肝母细胞瘤中的作用

Cristóbal Ion, Sanz-Álvarez Marta, Luque Melani, Caramés Cristina, Rojo Federico, García-Foncillas Jesús

Cancer Unit for Research on Novel Therapeutic Targets, Oncohealth Institute, IIS-Fundación Jiménez Díaz-UAM, E-28040 Madrid, Spain.

Translational Oncology Division, Oncohealth Institute, IIS-Fundación Jiménez Díaz-UAM, E-28040 Madrid, Spain.

Cancers (Basel). 2019 Mar 22;11(3):409. doi: 10.3390/cancers11030409.

Hepatoblastoma is the most common hepatic malignancy during childhood. However, little is still known about the molecular mechanisms that govern the development of this disease. This review is focused on the recent advances regarding the study of microRNAs in hepatoblastoma and their substantial contribution to improv our knowledge of the pathogenesis of this disease. We show here that miRNAs represent valuable tools to identify signaling pathways involved in hepatoblastoma progression as well as useful biomarkers and novel molecular targets to develop alternative therapeutic strategies in this disease.

肝母细胞瘤是儿童期最常见的肝脏恶性肿瘤。然而，关于该疾病发生发展的分子机制仍知之甚少。本综述聚焦于肝母细胞瘤中微小RNA研究的最新进展，以及它们对增进我们对该疾病发病机制认识的重大贡献。我们在此表明，微小RNA是识别参与肝母细胞瘤进展的信号通路的有价值工具，也是开发该疾病替代治疗策略的有用生物标志物和新型分子靶点。