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吲哚合成咔唑的最新进展。

Recent advances in the synthesis of carbazoles from indoles.

机构信息

Synthetic Organic Chemistry Laboratory, Department of Chemistry, University of Delhi, Delhi-110007, India.

出版信息

Org Biomol Chem. 2019 Sep 28;17(36):8330-8342. doi: 10.1039/c9ob01381d. Epub 2019 Sep 9.

Abstract

Carbazoles are privileged nitrogen heterocycles that are present in a wide range of natural products, pharmaceuticals, and functional materials. Due to their wide application, various synthetic strategies are available in the literature using substituted amines or indoles as a substrate. Thus, this review comprehensively highlights the (2015-2019) article that focuses on the synthesis of carbazoles derived from an indole-template through transition-metal catalyzed C-H functionalization, metal-free cyclization, three-component reaction, and electrophilic iodocyclizations. The synthetic strategies described in this review provided diversely substituted carbazoles and few of them have profound pharmacological activity.

摘要

咔唑类化合物是一类具有重要意义的含氮杂环化合物,广泛存在于天然产物、药物和功能材料中。由于其广泛的应用,文献中已经报道了多种合成策略,这些策略使用取代的胺或吲哚作为底物。因此,本综述全面地介绍了(2015-2019 年)重点关注通过过渡金属催化 C-H 功能化、无金属环化、三组分反应和亲电碘化环化,从吲哚模板衍生的咔唑类化合物的合成的文章。本综述中描述的合成策略提供了各种取代的咔唑类化合物,其中一些具有深远的药理学活性。

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