Zerihun Kassaw Wubneh, Bikis Gashaw Andargie, Muhammad Esmael Ali
Debre Tabor Health Science College, P.O. Box 196, Gondar, Ethiopia.
Department of Health Service Management, Institute of Public Health, University of Gondar, P.O. Box 196, Gondar, Ethiopia.
BMC Res Notes. 2019 Mar 25;12(1):168. doi: 10.1186/s13104-019-4214-3.
Anemia is the most common hematological complication of HIV infection that has a significant impact on the quality of life and clinical outcomes. Therefore, the aim of this study was to assess the prevalence and associated factors of anemia among adult HIV positive patients on Anti-retroviral therapy at Deber Tabor hospital, northwest Ethiopia. An institution based cross-sectional study was conducted on 365 HIV/AIDS patients on ART selected using the systematic random sampling technique. Blood samples were analyzed using the Cell-DYN 1800 automated hematology analyzer to measure hemoglobin. Bivariable and multivariable binary logistic regression analyzes were employed to find the predictors at p-value < 0 .2 and 0.05, respectively.
The overall prevalence of anemia was 34.0%[95% CI (29.0, 39.0)]; taking Zidovudine based antiretroviral regimen (AOR: 5.9, 95% CI 1.04, 13.86), CD4 count < 200 cells/mm (AOR: 4.8 95%, CI 1.14, 12.42), inability to read and write (AOR: 3.2, 95% CI (1.24,8.40), inadequate dietary diversity (AOR: 2.2, 95% CI 1.15, 4.26), and female sex (AOR: 1.9, 95% CI 1.06, 3.69) were significantly associated with increased odds of anemia. Therefore, routine screening of hemoglobin level, proper treatment of respondents on zidovudine based ART regimen and increasing productivity to improve dietary diversity are essential to prevent anemia.
贫血是HIV感染最常见的血液学并发症，对生活质量和临床结局有重大影响。因此，本研究旨在评估埃塞俄比亚西北部德伯塔博尔医院接受抗逆转录病毒治疗的成年HIV阳性患者中贫血的患病率及相关因素。采用系统随机抽样技术，对365例接受抗逆转录病毒治疗的HIV/AIDS患者进行了一项基于机构的横断面研究。使用Cell-DYN 1800自动血液分析仪分析血样以测量血红蛋白。分别采用双变量和多变量二元逻辑回归分析，在p值<0.2和0.05时寻找预测因素。
贫血的总体患病率为34.0%[95%置信区间(29.0, 39.0)]；采用基于齐多夫定的抗逆转录病毒治疗方案（调整后比值比：5.9，95%置信区间1.04, 13.86）、CD4细胞计数<200个/mm（调整后比值比：4.8，95%置信区间1.14, 12.42）、不识字（调整后比值比：3.2，95%置信区间(1.24, 8.40)）、饮食多样性不足（调整后比值比：2.2，95%置信区间1.15, 4.26）以及女性（调整后比值比：1.9，95%置信区间1.06, 3.69）与贫血几率增加显著相关。因此，常规筛查血红蛋白水平、对接受基于齐多夫定的抗逆转录病毒治疗方案的患者进行适当治疗以及提高生产力以改善饮食多样性对于预防贫血至关重要。
