Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey.
Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey.
J Trace Elem Med Biol. 2019 May;53:150-153. doi: 10.1016/j.jtemb.2019.03.004. Epub 2019 Mar 9.
Boron (B) compounds are essential for plants and animals and beneficial for humans in nutritional amounts. I animals and humans increasing evidence have shown beneficial effects on B compounds on nutrition and on antioxidant status. The genotoxic effects of environmental B exposure in women living in boron-rich and boron-poor areas was examined in this study. For this purpose, the DNA damage in the lymphocytes and buccal cells of females were assessed by Comet and micronucleus (MN) assays respectively. No significant difference was observed in the DNA damage of the lymphocytes of B exposed groups of female volunteers in Comet assay. Even buccal micronucleus (MN) frequency observed in the high exposure group was significantly lower than the low exposure group (p < 0.05). The results of this study came to the same conclusions of the previous studies that boron does not induce DNA damage even under extreme exposure conditions.
硼（B）化合物对动植物至关重要，适量摄入对人体也有益。越来越多的证据表明，B 化合物对营养和抗氧化状态有有益影响。本研究旨在检测生活在富硼和贫硼地区的女性的环境硼暴露的遗传毒性效应。为此，通过彗星试验和微核（MN）试验分别评估了女性淋巴细胞和口腔细胞中的 DNA 损伤。在彗星试验中，B 暴露组女性志愿者的淋巴细胞 DNA 损伤无显著差异。即使在高暴露组中观察到的口腔微核（MN）频率也显著低于低暴露组（p<0.05）。这项研究的结果与之前的研究得出了相同的结论，即在极端暴露条件下，硼甚至不会引起 DNA 损伤。
