Latruffe N, Berrez J M, el Kebbaj M S
Biochimie. 1986 Mar;68(3):481-91. doi: 10.1016/s0300-9084(86)80015-3.
Since the biological membranes are fundamental units in the living cells, the studies of lipid-protein interactions are crucial for the understanding of their structure, functions and properties. Beside hydrophobic interactions between fatty acids chain of phospholipids and intrinsic membrane proteins, the interactions between charged groups of the protein with the polar heads of phospholipids generally confer the specificity which may be absolute or preferential. This paper reports essential results obtained these last few years with D-beta-hydroxybutyrate dehydrogenase (BDH) from inner mitochondrial membrane, one of the most interesting and best documented examples of a lipid-requiring enzyme. This is a review of the molecular basis--knowledge and strategy of study--of the lipid specificity for membrane protein functions.
由于生物膜是活细胞的基本单位，因此研究脂质 - 蛋白质相互作用对于理解其结构、功能和特性至关重要。除了磷脂脂肪酸链与内在膜蛋白之间的疏水相互作用外，蛋白质的带电基团与磷脂极性头部之间的相互作用通常赋予特异性，这种特异性可能是绝对的或优先的。本文报道了近年来从线粒体内膜中获得的关于D-β-羟丁酸脱氢酶（BDH）的重要结果，BDH是需要脂质的酶中最有趣且记录最完善的例子之一。这是一篇关于膜蛋白功能脂质特异性的分子基础——知识和研究策略的综述。
