Moradzadeh Rahmatollah, Anoushirvani Ali Arash
Department of Epidemiology, School of Health, Arak University of Medical Sciences, Arak, Iran.
School of Medicine, Arak University of Medical Sciences, Arak, Iran.
J Gastrointest Cancer. 2020 Mar;51(1):159-164. doi: 10.1007/s12029-019-00227-8.
There are remarkable differences between the incidence and mortality of gastric cancer in different places of the world. This study, for the first time, estimated the information around the incidence rates and trends of gastric cancer in the central area of Iran, Arak metropolitan.
In this study, all cases with gastric cancer in Arak from 2009 to 2014 were included. Direct standardized method was applied to estimate age-standardized incidence rates (ASIRs) by a STATA package, with efficient interval estimation that might be preferable in the case of rare diseases, including cancer data. The obtained standard errors were used to calculate annual percent changes (APCs) by the Joinpoint analysis.
Annual ASIRs of gastric cancer were 23.92 (95% CI 21.62, 26.37) and 9.60 (95% CI 8.20, 11.18) for male and female, respectively. In male, APC of ASIRs was - 5.00% (95% CI - 9.32, - 0.47). In contrast, among female, it was - 2.69% (95% CI - 31.56, 38.34) that was statistically insignificant.
The ASIRs have significantly decreased trends in males, but not in females. The preventive strategies should be a focus on the declining of the risk factors and the quick early diagnosis of gastric cancer.
世界不同地区胃癌的发病率和死亡率存在显著差异。本研究首次估计了伊朗中部阿拉克市胃癌发病率及趋势的相关信息。
本研究纳入了2009年至2014年阿拉克市所有胃癌病例。采用直接标准化方法，通过STATA软件包估计年龄标准化发病率（ASIRs），并进行有效区间估计，这在包括癌症数据在内的罕见病情况下可能更可取。利用获得的标准误，通过Joinpoint分析计算年度百分比变化（APCs）。
男性和女性胃癌的年度ASIRs分别为23.92（95%CI 21.62，26.37）和9.60（95%CI 8.20，11.18）。男性ASIRs的APCs为-5.00%（95%CI -9.32，-0.47）。相比之下，女性为-2.69%（95%CI -31.56，38.34），无统计学意义。
男性的ASIRs呈显著下降趋势，而女性则不然。预防策略应侧重于降低危险因素以及胃癌的快速早期诊断。
