• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Small molecules as central nervous system therapeutics: old challenges, new directions, and a philosophic divide.

作者信息

Banks William A, Greig Nigel H

机构信息

Geriatric Research Education & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.

Division of Gerontology & Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.

出版信息

Future Med Chem. 2019 Mar;11(6):489-493. doi: 10.4155/fmc-2018-0436. Epub 2019 Mar 26.

DOI:10.4155/fmc-2018-0436
PMID:30912980
Abstract
摘要

相似文献

1
Small molecules as central nervous system therapeutics: old challenges, new directions, and a philosophic divide.作为中枢神经系统治疗药物的小分子:旧挑战、新方向及理念分歧
Future Med Chem. 2019 Mar;11(6):489-493. doi: 10.4155/fmc-2018-0436. Epub 2019 Mar 26.
2
Delivery of therapeutic agents to the central nervous system: the problems and the possibilities.向中枢神经系统输送治疗药物:问题与可能性
Pharmacol Ther. 2004 Oct;104(1):29-45. doi: 10.1016/j.pharmthera.2004.08.001.
3
Delivery of therapeutics to the central nervous system.将治疗药物递送至中枢神经系统。
Adv Drug Deliv Rev. 2012 May 15;64(7):589. doi: 10.1016/j.addr.2012.02.009. Epub 2012 Feb 24.
4
Selecting Good 'Drug-Like' Properties to Optimize Small Molecule Blood-Brain Barrier Penetration.选择良好的“类药”性质以优化小分子的血脑屏障穿透性。
Curr Med Chem. 2016;23(14):1392-407. doi: 10.2174/0929867323666160405112353.
5
Applications of nanotechnology in drug delivery to the central nervous system.纳米技术在药物递送至中枢神经系统中的应用。
Biomed Pharmacother. 2019 Mar;111:666-675. doi: 10.1016/j.biopha.2018.12.133. Epub 2019 Jan 3.
6
From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery.从血脑屏障到血脑界面:中枢神经系统药物递送的新机遇。
Nat Rev Drug Discov. 2016 Apr;15(4):275-92. doi: 10.1038/nrd.2015.21. Epub 2016 Jan 22.
7
Current State and Future Perspectives in QSAR Models to Predict Blood- Brain Barrier Penetration in Central Nervous System Drug R&D.用于预测中枢神经系统药物研发中血脑屏障通透性的定量构效关系模型的现状与未来展望
Mini Rev Med Chem. 2017;17(3):247-257. doi: 10.2174/1389557516666161013110813.
8
Structural modifications that alter the P-glycoprotein efflux properties of compounds.改变化合物P-糖蛋白外排特性的结构修饰。
J Med Chem. 2012 Jun 14;55(11):4877-95. doi: 10.1021/jm201136z. Epub 2012 Apr 16.
9
Intranasal delivery of biologics to the central nervous system.经鼻内递送至中枢神经系统的生物制剂。
Adv Drug Deliv Rev. 2012 May 15;64(7):614-28. doi: 10.1016/j.addr.2011.11.002. Epub 2011 Nov 15.
10
Nanowired Drug Delivery Across the Blood-Brain Barrier in Central Nervous System Injury and Repair.纳米线药物递送跨越血脑屏障用于中枢神经系统损伤与修复
CNS Neurol Disord Drug Targets. 2016;15(9):1092-1117. doi: 10.2174/1871527315666160819123059.

引用本文的文献

1
Development of Brain Permeable Drugs and Novel Strategies to Overcome the Brain Barriers for Treatment Purposes.用于治疗目的的脑渗透性药物的开发及克服血脑屏障的新策略。
Curr Pharm Des. 2025 Apr 21. doi: 10.2174/0113816128386983250410092649.
2
Metal nanoparticles in neuroinflammation: impact on microglial dynamics and CNS function.神经炎症中的金属纳米颗粒:对小胶质细胞动力学和中枢神经系统功能的影响。
RSC Adv. 2025 Feb 18;15(7):5426-5451. doi: 10.1039/d4ra07798a. eCollection 2025 Feb 13.
3
Systematic Study of Steroid Drugs' Ability to Cross Biomembranes-The Possible Environmental Impact and Health Risks Associated with Exposure During Pregnancy.
类固醇药物跨生物膜能力的系统研究——孕期接触相关的潜在环境影响与健康风险
Membranes (Basel). 2024 Dec 26;15(1):4. doi: 10.3390/membranes15010004.
4
Control of neurovascular coupling by ATP-sensitive potassium channels.ATP敏感性钾通道对神经血管耦合的调控。
J Cereb Blood Flow Metab. 2025 Jun;45(6):1130-1143. doi: 10.1177/0271678X251313906. Epub 2025 Jan 17.
5
The Benzoxazole Heterocycle: A Comprehensive Review of the Most Recent Medicinal Chemistry Developments of Antiproliferative, Brain-Penetrant, and Anti-inflammatory Agents.苯并恶唑杂环:抗增殖、穿透血脑屏障和抗炎药物的最新药物化学发展的综合综述。
Top Curr Chem (Cham). 2024 Oct 21;382(4):33. doi: 10.1007/s41061-024-00477-6.
6
Unveiling the hidden connection: the blood-brain barrier's role in epilepsy.揭示隐藏的联系:血脑屏障在癫痫中的作用。
Front Neurol. 2024 Aug 14;15:1413023. doi: 10.3389/fneur.2024.1413023. eCollection 2024.
7
Rapid Biofabrication of an Advanced Microphysiological System Mimicking Phenotypical Heterogeneity and Drug Resistance in Glioblastoma.快速生物制造一种模拟胶质母细胞瘤表型异质性和耐药性的先进微生理系统
Adv Healthc Mater. 2024 Dec;13(30):e2401876. doi: 10.1002/adhm.202401876. Epub 2024 Aug 5.
8
Effects of Sodium Nitroprusside on Lipopolysaccharide-Induced Inflammation and Disruption of Blood-Brain Barrier.硝普钠对脂多糖诱导的炎症和血脑屏障破坏的影响。
Cells. 2024 May 15;13(10):843. doi: 10.3390/cells13100843.
9
A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors.小体积蕴含大能量:利用吡啶酮类化合物发现可穿透中枢神经系统的氮杂吲唑 IRAK4 抑制剂
ACS Med Chem Lett. 2024 Apr 26;15(5):714-721. doi: 10.1021/acsmedchemlett.4c00102. eCollection 2024 May 9.
10
The role of oxidative stress in blood-brain barrier disruption during ischemic stroke: Antioxidants in clinical trials.氧化应激在缺血性脑卒中期间血脑屏障破坏中的作用:临床试验中的抗氧化剂。
Biochem Pharmacol. 2024 Oct;228:116186. doi: 10.1016/j.bcp.2024.116186. Epub 2024 Mar 30.