Fierlbeck G, Rassner G
Dtsch Med Wochenschr. 1986 Aug 29;111(35):1313-6. doi: 10.1055/s-2008-1068626.
Fifteen patients with confirmed psoriatic arthritis were treated with recombinant interferon-gamma (IFN-gamma) between October 1985 and February 1986. In ten patients a marked relief of joint pain was achieved within 28 days. Daily doses of less than 200 micrograms IFN-gamma did not have any effect on the skin lesions. Tolerance of the drug, given subcutaneously, was dose-dependent, no side-effects occurred with dosages of less than 100 micrograms/d.
1985年10月至1986年2月期间,15例确诊为银屑病关节炎的患者接受了重组干扰素-γ(IFN-γ)治疗。10例患者在28天内关节疼痛明显缓解。每日剂量低于200微克的IFN-γ对皮肤病变没有任何影响。皮下注射该药物的耐受性呈剂量依赖性,剂量低于100微克/天时未出现副作用。