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成骨过程中的长链非编码RNA：一个有待探索的新领域。

Long non-coding RNA in osteogenesis: A new world to be explored.

作者信息

Zhang J, Hao X, Yin M, Xu T, Guo F

机构信息

Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Biochemistery and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina, North Carolina, USA.

Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

出版信息

Bone Joint Res. 2019 Mar 2;8(2):73-80. doi: 10.1302/2046-3758.82.BJR-2018-0074.R1. eCollection 2019 Feb.

DOI:10.1302/2046-3758.82.BJR-2018-0074.R1
PMID:30915213
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6397330/
Abstract

Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides with limited coding potential, which have emerged as novel regulators in many biological and pathological processes, including growth, development, and oncogenesis. Accumulating evidence suggests that lncRNAs have a special role in the osteogenic differentiation of various types of cell, including stem cells from different sources such as embryo, bone marrow, adipose tissue and periodontal ligaments, and induced pluripotent stem cells. Involved in complex mechanisms, lncRNAs regulate osteogenic markers and key regulators and pathways in osteogenic differentiation. In this review, we provide insights into the functions and molecular mechanisms of lncRNAs in osteogenesis and highlight their emerging roles and clinical value in regenerative medicine and osteogenesis-related diseases. : J. Zhang, X. Hao, M. Yin, T. Xu, F. Guo. Long non-coding RNA in osteogenesis: A new world to be explored. 2019;8:73-80. DOI: 10.1302/2046-3758.82.BJR-2018-0074.R1.

摘要

长链非编码RNA（lncRNAs）是一类长度超过200个核苷酸且编码潜能有限的转录本，在包括生长、发育和肿瘤发生在内的许多生物学和病理过程中已成为新型调节因子。越来越多的证据表明，lncRNAs在包括胚胎、骨髓、脂肪组织和牙周韧带等不同来源的干细胞以及诱导多能干细胞在内的各类细胞的成骨分化中发挥着特殊作用。lncRNAs参与复杂机制，调控成骨标志物以及成骨分化中的关键调节因子和信号通路。在本综述中，我们深入探讨了lncRNAs在骨生成中的功能和分子机制，并强调了它们在再生医学和成骨相关疾病中日益凸显的作用及临床价值。: J. Zhang, X. Hao, M. Yin, T. Xu, F. Guo. 骨生成中的长链非编码RNA：一个有待探索的新世界。2019;8:73 - 80。DOI: 10.1302/2046 - 3758.82.BJR - 2018 - 0074.R1。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070c/6397330/0dba2bfc0896/bonejointres-08-73-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070c/6397330/48caa49c5200/bonejointres-08-73-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070c/6397330/77423784f0ce/bonejointres-08-73-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070c/6397330/a58eb975efd8/bonejointres-08-73-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070c/6397330/0dba2bfc0896/bonejointres-08-73-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070c/6397330/48caa49c5200/bonejointres-08-73-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070c/6397330/77423784f0ce/bonejointres-08-73-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070c/6397330/a58eb975efd8/bonejointres-08-73-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070c/6397330/0dba2bfc0896/bonejointres-08-73-g004.jpg

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