Hasan Osamah, Patel Ankit A, Siegert James J
Midwestern University, 555 31st St., Downers Grove, IL 60515, USA.
Franciscan Health, 20201 South Crawford Avenue, Olympia Fields, IL 60461, USA.
Case Rep Med. 2019 Feb 24;2019:6327819. doi: 10.1155/2019/6327819. eCollection 2019.
Recreational use of synthetic cannabinoids (SCs), also known as "K2" or "Spice," is becoming a major public-health concern due to their potential for abuse and harmful consequences. New substances are constantly being added to the content of SCs. The dearth of information on these newly added contents as they are introduced into the black market hinders risk assessments of these compounds. We report a highly unusual case of gross hematuria in a 28-year-old male patient after SC use. He was found to have a supratherapeutic INR with no history of prior anticoagulation. His hematuria resolved after four units of fresh-frozen plasma were administered. We include a literature review of the clinical effects of SCs and their possible mechanism of gross hematuria and management.
合成大麻素（SCs），也被称为“K2”或“香料”，其在娱乐用途上的使用因其潜在的滥用可能性和有害后果正成为一个主要的公共卫生问题。新的物质不断被添加到合成大麻素的成分中。当这些新添加的成分被引入黑市时，关于它们的信息匮乏阻碍了对这些化合物的风险评估。我们报告了一例28岁男性患者在使用合成大麻素后出现严重血尿的非常罕见的病例。他被发现国际标准化比值（INR）高于治疗水平，且既往无抗凝治疗史。在输注了4单位新鲜冰冻血浆后，他的血尿症状得到缓解。我们纳入了一篇关于合成大麻素临床效应及其导致严重血尿的可能机制和处理方法的文献综述。
