Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.
Department of Biology, College of Science and Mathematics, Augusta University, Augusta, GA, USA.
Adv Exp Med Biol. 2019;1134:243-258. doi: 10.1007/978-3-030-12668-1_13.
Phosphofructokinase-1 (PFK-1), a rate-determining enzyme of glycolysis, is an allosteric enzyme that regulates the oxidation of glucose in cellular respiration. Glycolysis phosphofructokinase platelet (PFKP) is the platelet isoform and works as an important mediator of cell metabolism. Considering that PFKP is a crucial player in many steps of cancer initiation and metastasis, we reviewed the specificities and complexities of PFKP and its biological roles in human diseases, especially malignant tumors. The possible use of PFKP as a diagnostic marker or a drug target in the prevention or treatment of cancer is also discussed.
磷酸果糖激酶-1（PFK-1）是糖酵解的限速酶，是一种调节细胞呼吸中葡萄糖氧化的变构酶。糖酵解磷酸果糖激酶血小板（PFKP）是血小板同工酶，作为细胞代谢的重要介质。考虑到 PFKP 是癌症发生和转移的许多步骤中的关键参与者，我们综述了 PFKP 的特异性和复杂性及其在人类疾病中的生物学作用，特别是恶性肿瘤。还讨论了 PFKP 作为诊断标志物或药物靶点在癌症的预防或治疗中的可能用途。
