Department of Dermatology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
ResoVerneuil, Paris, France.
Br J Dermatol. 2019 Dec;181(6):1198-1206. doi: 10.1111/bjd.17927. Epub 2019 May 6.
Hidradenitis suppurativa (HS), also referred to as acne inversa, is a debilitating skin disease characterized by inflammatory nodules, chronic abscesses and tunnels (fistulae and sinuses). The association with pilonidal sinus disease (PSD) is frequently reported but not well documented.
To determine the prevalence and characteristics of inflammatory skin lesions located in the intergluteal fold (IGF) of patients with HS.
This was an international multicentre retrospective cross-sectional study based on data collection from a large cohort of patients with HS with and without histopathology. Results From a total of 2465 patients with HS included in the study, 661 (27%) reported lesions in the IGF. These patients were significantly more often smokers and had more severe HS. Of the 238 patients with an available clinical diagnosis, intergluteal-HS (IG-HS) was diagnosed in 52 patients (22%) and PSD was diagnosed in 186 patients (78%). IG-HS was associated with the localization of HS in the proximity of the IGF, including the buttocks, genitals and the anus. There was a possibility of misclassification bias in this study as a clinical/image-based diagnosis or histopathology of the IGF lesions was not always available.
The high prevalence of PSD suggests a strong link between both entities. Therefore, it may be useful to identify common pathophysiological mechanisms and develop common therapeutic strategies. What's already known about this topic? The occurrence of pilonidal sinus disease has not been clearly reported among patients with hidradenitis suppurativa/acne inversa. What does this study add? This is the first study that investigated the prevalence of pilonidal sinus disease among a large cohort of patients and identified the patient characteristics. Risk factors that might help to improve the management of patients were identified.
化脓性汗腺炎（HS），也称为反向痤疮，是一种使人衰弱的皮肤病，其特征为炎症性结节、慢性脓肿和瘘管（瘘和窦道）。化脓性汗腺炎与藏毛窦病（PSD）的相关性经常被报道，但并未得到很好的记录。
确定患有化脓性汗腺炎的患者臀部褶皱（IGF）中炎症性皮肤病变的患病率和特征。
这是一项基于大型化脓性汗腺炎患者队列的国际多中心回顾性横断面研究，对数据进行了收集。在研究中，共有 2465 例化脓性汗腺炎患者，其中 661 例（27%）报告在 IGF 有病变。这些患者明显更多为吸烟者，且化脓性汗腺炎更严重。在 238 例可获得临床诊断的患者中，诊断为臀间化脓性汗腺炎（IG-HS）的患者有 52 例（22%），诊断为 PSD 的患者有 186 例（78%）。IG-HS 与 IGF 附近的化脓性汗腺炎的定位有关，包括臀部、生殖器和肛门。由于该研究中可能存在临床/图像为基础的诊断的偏倚，因此 IGF 病变的组织病理学诊断并非总是可用。
PSD 的高患病率表明这两种疾病之间存在很强的联系。因此，确定共同的病理生理机制并制定共同的治疗策略可能是有用的。
本研究主题已知哪些内容？化脓性汗腺炎患者中藏毛窦病的发生情况尚未明确报道。本研究增加了哪些新内容？这是第一项研究，调查了大型患者队列中藏毛窦病的患病率，并确定了患者特征。确定了可能有助于改善患者管理的危险因素。
