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儿童化脓性汗腺炎的临床特征:一项横断面多中心研究,共纳入 140 例患者。

Clinical characteristics of pediatric hidradenitis suppurativa: a cross-sectional multicenter study of 140 patients.

机构信息

Department of Dermatology, Zealand University Hospital, Sygehusvej 5, 4000, Roskilde, Denmark.

Health Sciences Faculty, University of Copenhagen, Copenhagen, Denmark.

出版信息

Arch Dermatol Res. 2020 Dec;312(10):715-724. doi: 10.1007/s00403-020-02053-6. Epub 2020 Mar 12.

Abstract

Hidradenitis suppurativa (HS) rarely affects pediatric patients. The literature on pediatric HS patients is scarce. This is a cross-sectional study based on case note review or interviews and clinical examination of 140 pediatric patients undergoing secondary or tertiary level care. Patients were predominantly female (75.5%, n = 105) with a median age of 16. 39% reported 1st-degree relative with HS. Median BMI percentile was 88, and 11% were smokers (n = 15). Median modified Sartorius score was 8.5. Notable comorbidities found were acne (32.8%, n = 45), hirsutism (19.3%, n = 27), and pilonidal cysts (16.4%, n = 23). Resorcinol (n = 27) and clindamycin (n = 25) were the most frequently used topical treatments. Patients were treated with tetracycline (n = 32), or oral clindamycin and rifampicin in combination (n = 29). Surgical excision was performed in 18 patients, deroofing in five and incision in seven patients. Obesity seemed to be prominent in the pediatric population and correlated to parent BMI, suggesting a potential for preventive measures for the family. Disease management appeared to be similar to that of adult HS, bearing in mind that the younger the patient, the milder the disease in majority of cases.

摘要

化脓性汗腺炎(HS)很少影响儿科患者。关于儿科 HS 患者的文献很少。这是一项基于病历回顾或访谈以及对 140 名接受二级或三级护理的儿科患者进行临床检查的横断面研究。患者主要为女性(75.5%,n=105),中位年龄为 16.39%的患者报告有一级亲属患有 HS。中位 BMI 百分位数为 88,11%的患者吸烟(n=15)。中位改良 Sartorius 评分 8.5。发现的显著合并症包括痤疮(32.8%,n=45)、多毛症(19.3%,n=27)和藏毛窦(16.4%,n=23)。间苯二酚(n=27)和克林霉素(n=25)是最常用的局部治疗药物。患者接受四环素(n=32)或口服克林霉素和利福平联合治疗(n=29)。18 名患者接受了手术切除,5 名患者接受了去顶术,7 名患者接受了切开术。肥胖在儿科人群中似乎很突出,与父母 BMI 相关,表明对家庭有预防措施的潜力。疾病管理似乎与成人 HS 相似,需要注意的是,大多数情况下,患者年龄越小,疾病越轻。

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