Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
Non-Communicable Disease Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
East Mediterr Health J. 2019 Mar 19;25(1):47-57. doi: 10.26719/emhj.18.014.
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide.
To synthesize data on the worldwide prevalence and severity of COPD by geographical region, age groups, and smoking status in a systematic review.
A systematic search was performed following Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines. International databases including PubMed, Scopus and Web of Science were searched for population- based studies published between January 2004 and May 2015 that reported the prevalence of COPD anywhere in the world. The prevalence of COPD was calculated based on World Health Organization (WHO) regions and sex and severity stages using metaprop. Meta-regression and subgroup analysis were applied to determine the sources of heterogeneity.
Sixty papers were screened with a combined subject sample size of 127 598. The prevalence of post-bronchodilator COPD was 12.16% (10.91-13.40%). The pooled prevalence of COPD was 15.70% (13.80-18.59%) in men and 9.93% (8.73- 11.13%) in women. Among all WHO regions, the highest prevalence was recorded in the Region of the Americas (14.53%), and the lowest was recorded in the South-East Asia Region/Western Pacific Region (8.80%). Meta-regression model variables were: sample size, WHO region, study quality score, level of gathering data, publication year, and sampling methods that justified 29.82% of heterogeneity detected among COPD prevalence rates worldwide.
Global prevalence of COPD among men is about 5% higher than among women. The most prevalent stage of COPD is stage 1.
慢性阻塞性肺疾病（COPD）是全球发病率和死亡率的主要原因。
通过系统评价，综合全球不同地理区域、年龄组和吸烟状况下 COPD 的流行率和严重程度数据。
按照观察性研究荟萃分析（MOOSE）指南进行系统检索。检索了包括 PubMed、Scopus 和 Web of Science 在内的国际数据库，以获取 2004 年 1 月至 2015 年 5 月期间发表的全球 COPD 流行率的基于人群的研究报告。采用 metaprop 基于世界卫生组织（WHO）区域和性别以及严重程度阶段计算 COPD 的流行率。应用 Meta 回归和亚组分析确定异质性的来源。
筛选了 60 篇论文，共纳入了 127598 例研究对象。支气管扩张剂后 COPD 的患病率为 12.16%（10.91-13.40%）。COPD 的总患病率为男性 15.70%（13.80-18.59%）和女性 9.93%（8.73-11.13%）。在所有 WHO 区域中，患病率最高的是美洲区域（14.53%），最低的是东南亚/西太平洋区域（8.80%）。Meta 回归模型变量包括：样本量、WHO 区域、研究质量评分、数据收集水平、发表年份和抽样方法，这些变量解释了全球 COPD 患病率差异的 29.82%。
全球男性 COPD 的患病率约比女性高 5%。COPD 最常见的阶段是 1 期。
