van der Zee J S, Beuvery E C, van Ree R, Aalberse R C
Mol Immunol. 1986 Jun;23(6):669-73. doi: 10.1016/0161-5890(86)90105-7.
Activation of guinea-pig complement by human IgM antibodies after interaction with a particulate antigen is well established. Human IgM antibodies directed against meningococcal group-C capsular polysaccharide, however, were not able to fix guinea-pig complement in a classical complement fixation test with soluble antigen. In the same test, human complement was readily activated by these antibodies. This inability of human IgM antibodies to activate guinea-pig complement after interaction with soluble antigen was confirmed in other antigen systems. In contrast, efficient activation of both human and guinea-pig complement was found with the same antigen in a particulate form.
人IgM抗体与颗粒性抗原相互作用后激活豚鼠补体已得到充分证实。然而，在针对C群脑膜炎球菌荚膜多糖的人IgM抗体与可溶性抗原进行的经典补体结合试验中，这些抗体无法固定豚鼠补体。在同一试验中，这些抗体能轻易激活人补体。在其他抗原系统中也证实了人IgM抗体与可溶性抗原相互作用后无法激活豚鼠补体。相比之下，相同抗原以颗粒形式存在时，人和豚鼠补体均可有效激活。
