Sjouke T, Zwanenburg B, van Buul P P
Mutat Res. 1986 Sep;175(1):33-7. doi: 10.1016/0165-7992(86)90142-9.
The effect of 3-aminobenzamide (3AB) treatment on chromosomal radiosensitivity of mouse spermatogonial stem cells and bone-marrow cells was studied using various doses of X-rays. The results show that 3AB increases the induction of reciprocal translocations in slowly cycling spermatogonia as well as the frequency of chromosomal aberrations in actively dividing bone-marrow cells. The experiments indicate that both types of tissue are suitable to study the ability of inhibitors of ADP-ribosylation to modulate chromosome-breaking damage induced by ionizing radiation in vivo.
使用不同剂量的X射线研究了3-氨基苯甲酰胺（3AB）处理对小鼠精原干细胞和骨髓细胞染色体辐射敏感性的影响。结果表明，3AB增加了慢周期精原细胞中相互易位的诱导以及活跃分裂的骨髓细胞中染色体畸变的频率。实验表明，这两种组织都适合用于研究ADP-核糖基化抑制剂在体内调节电离辐射诱导的染色体断裂损伤的能力。
