Eveleth D D, Marsh J L
Nucleic Acids Res. 1986 Aug 11;14(15):6169-83. doi: 10.1093/nar/14.15.6169.
A transcript has been localized proximal to the dopa decarboxylase (Ddc) gene within a cluster of genes involved in cuticle formation and catecholamine metabolism in Drosophila. This gene, which has been identified as I(2)37Cc, maps 2.0kb from the 5' end of the Ddc gene and is transcribed in the same direction as Ddc. We describe a new deficiency which in conjunction with previous deficiencies localizes the I(2)37Cb and I(2)37Cc loci to the cytogenetic interval 5' to Ddc. We present the sequence of the Cc gene and corresponding cDNA. The Cc message contains several open reading frames 5' to the large open reading frame responsible for the lethal complementation group, suggesting that expression of Cc function may be regulated translationally. The Cc transcript is expressed in early embryos, late embryos, late third instar larvae and adults. We discuss the implications of these findings with respect to the gene organization in the region.
一份转录本定位于果蝇中参与表皮形成和儿茶酚胺代谢的一组基因内多巴脱羧酶（Ddc）基因的近端。该基因已被鉴定为I(2)37Cc，位于距Ddc基因5'端2.0kb处，并与Ddc同向转录。我们描述了一种新的缺失，它与先前的缺失一起将I(2)37Cb和I(2)37Cc基因座定位到细胞遗传学区间5'至Ddc。我们给出了Cc基因和相应cDNA的序列。Cc信息在负责致死互补群的大开放阅读框5'端包含几个开放阅读框，这表明Cc功能的表达可能在翻译水平上受到调控。Cc转录本在早期胚胎、晚期胚胎、晚期三龄幼虫和成虫中表达。我们讨论了这些发现对该区域基因组织的影响。
