Department of Inorganic and Analytical Chemistry, Medical University of Bialystok, Poland.
Chem Phys Lipids. 2019 Jul;221:46-52. doi: 10.1016/j.chemphyslip.2019.03.011. Epub 2019 Mar 25.
The products of lipid peroxidation, resulting from cell metabolism as well as the action of external physical factors and xenobiotics, have a significant impact on cell functions. One of the mechanisms by which lipid peroxidation products influence cells is the formation of adducts with proteins, including enzymes and signaling molecules. This review describes the biological consequences of protein adduct formation with oxidative lipid fragmentation products such as 4-hydroxynonenal (4-HNE), malondialdehyde (MDA), and acrolein, as well as cyclization products including isoprostanes, isoketals, and isolevuglandins. The generation of protein adducts with lipid peroxidation products can stimulate the antioxidant system, which may also possess proinflammatory or proapoptotic effects. However, the role of adducts between lipid peroxidation products and proteins depends on the condition of the cells and can range from the function of cytoprotective activity stimulation, to induction of toxicity involved in the development of degenerative diseases.
脂质过氧化产物是细胞代谢以及外部物理因素和外源化学物质作用的结果，对细胞功能有重要影响。脂质过氧化产物影响细胞的机制之一是与蛋白质（包括酶和信号分子）形成加合物。本文综述了蛋白质与氧化脂质断裂产物（如 4-羟壬烯醛（4-HNE）、丙二醛（MDA）和丙烯醛）以及环化产物（如类异前列腺素、异酮和异戊烯基）形成加合物的生物学后果。脂质过氧化产物与蛋白质形成加合物会刺激抗氧化系统，这也可能具有促炎或促凋亡作用。然而，脂质过氧化产物与蛋白质之间加合物的作用取决于细胞的状况，其范围可以从刺激细胞保护活性的功能到参与退行性疾病发展的毒性诱导。
