Pacheco-Hernández Brenda, Ayora-Talavera Teresa, Cano-Sosa Julia, Noriega Lilia G, Pacheco-López Neith Aracely, Vargas-Morales Juan M, Medina-Vera Isabel, Guevara-Cruz Martha, Chim-Aké Rodolfo, Gutiérrez-Solis Ana Ligia, Lugo Roberto, Avila-Nava Azalia
Hospital Regional de Alta Especialidad de la Península de Yucatán, Servicios de Salud del Instituto Mexicano del Seguro Social para el Bienestar (IMSS-BIENESTAR), Mérida 97130, Yucatán, Mexico.
Centro De Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A. C. Subsede Sureste, Parque Científico Tecnológico de Yucatán, Sierra Papacal-Chuburná Puerto, Mérida 97302, Yucatán, Mexico.
Plants (Basel). 2025 Jul 2;14(13):2032. doi: 10.3390/plants14132032.
Urolithiasis (UL) is the presence of stones in the kidneys or urinary tract; its prevalence has increased worldwide. Thus, strategies have been sought to reduce it and one of them is the use of medicinal plants due to their accessibility, low cost, and cultural traditions. Studies on traditional medicinal plants in UL mainly documented results of litholytic and urinary parameters. Although, stone formation is related to oxidative stress and inflammation, and only a few studies are focused on these types of biomarkers. Thus, the aim of the present review was to summarize studies showing the antioxidant and anti-inflammatory effects of traditional medicinal plants used in UL management. We performed a scoping review; the database sources used were MEDLINE/PubMed, Google Scholar, SpringerLink, Scielo and Redalyc. From a total of 184 studies screened, six were included from China (2), India (3), and Corea (1). These studies have shown the antioxidant and anti-inflammatory effects of traditional medicinal plants, including (), (), (), (), () and (). They have also described their molecular mechanism of antioxidant and anti-inflammatory effects through the activation of antioxidant genes induced by Nrf2 or by suppressing the inflammatory gene expression by the inhibition of NFκ-B. These effects could be modulated by their bioactive compounds, such as polyphenols, flavonoids, tannins, saponins, and terpenes, present in these plants. This review summarizes the antioxidant and anti-inflammatory effects of traditional medicinal plants and highlights their molecular mechanisms of action and main bioactive compounds. This evidence may be used in biotechnology and synthetic biology areas for the development of new products from plant-derived compounds to reduce the high recurrence rates of UL.
尿石症（UL）是指在肾脏或尿路中存在结石；其在全球范围内的患病率呈上升趋势。因此，人们一直在寻求降低其患病率的策略，其中之一是使用药用植物，因为它们容易获取、成本低廉且具有文化传统。关于传统药用植物治疗尿石症的研究主要记录了溶石和尿液参数的结果。尽管结石形成与氧化应激和炎症有关，但只有少数研究关注这些类型的生物标志物。因此，本综述的目的是总结显示传统药用植物在尿石症管理中具有抗氧化和抗炎作用的研究。我们进行了一项范围综述；使用的数据库来源包括MEDLINE/PubMed、谷歌学术、SpringerLink、Scielo和Redalyc。在总共筛选的184项研究中，纳入了来自中国（2项）、印度（3项）和韩国（1项）的6项研究。这些研究显示了传统药用植物的抗氧化和抗炎作用，包括（）、（）、（）、（）、（）和（）。它们还描述了其抗氧化和抗炎作用的分子机制，即通过激活由Nrf2诱导的抗氧化基因或通过抑制NFκ-B来抑制炎症基因表达。这些作用可能由这些植物中存在的生物活性化合物调节，如多酚、黄酮类化合物、单宁、皂苷和萜类化合物。本综述总结了传统药用植物的抗氧化和抗炎作用，并突出了它们的作用分子机制和主要生物活性化合物。这一证据可用于生物技术和合成生物学领域，以开发源自植物化合物的新产品，从而降低尿石症的高复发率。
