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髂筋膜腔隙阻滞降低全髋关节置换术后的疼痛和阿片类药物消耗:系统评价和荟萃分析。

Fascia iliaca compartment block reduces pain and opioid consumption after total hip arthroplasty: A systematic review and meta-analysis.

机构信息

Department of Anesthesia, The First People's Hospital of Zhangjiagang, Soochow University, 215600, China.

Department of Anesthesia, The First People's Hospital of Zhangjiagang, Soochow University, 215600, China.

出版信息

Int J Surg. 2019 May;65:70-79. doi: 10.1016/j.ijsu.2019.03.014. Epub 2019 Mar 25.

Abstract

BACKGROUND

Optimal pain management after total hip arthroplasty (THA) remains controversial. We perform a meta-analysis from randomized controlled trials (RCTs) to evaluate the efficacy and safety of fascia iliaca compartment block (FICB) in THA.

METHODS

In this meta-analysis, we conducted electronic searches of Pubmed, Medline, Cochrane library, and Web of Science before February 2019. We collected RCTs to compare FICB and placebo for pain control after THA. The outcome measurements consisted of pain score, opioid consumption, length of hospitalization and postoperative complications. All data analyses were conducted using STATA 13.0. Cochrane Collaboration's tool was adopted to assess the risk of bias.

RESULTS

Seven RCTs met our inclusion criteria with 165 patients in the FICB groups, and 160 patients in the placebo groups. The present meta-analysis indicated that there were significant differences between the groups in terms of pain score at postoperative 12 h (WMD = -0.285, 95% CI [-0.460, -0.109], P = 0.002) and 24 h (WMD = -0.391, 95% CI [-0.723, -0.059], P = 0.021). FICB was associated with significant superior in opioid consumption at postoperative 12 h (WMD = -5.394, 95% CI [-8.772, -2.016], P = 0.002) and 24 h (WMD = -6.376, 95% CI [-10.737, -2.016], P = 0.004) compared with placebo. No significant difference was identified regarding length of hospitalization (WMD = 0.112, 95% CI [-0.125, 0.350], P = 0.354).

CONCLUSION

Fascia iliaca compartment block was effective for pain relief during the early post-operative period after total hip arthroplasty. Meanwhile, it reduced the cumulative morphine consumption and the risk of opioid-related adverse effects.

摘要

背景

全髋关节置换术后(THA)的最佳疼痛管理仍存在争议。我们对随机对照试验(RCT)进行荟萃分析,以评估股外侧肌间隔阻滞(FICB)在 THA 中的疗效和安全性。

方法

在这项荟萃分析中,我们在 2019 年 2 月之前对 Pubmed、Medline、Cochrane 图书馆和 Web of Science 进行了电子检索。我们收集了 RCTs,以比较 FICB 与安慰剂在 THA 后控制疼痛的效果。结果测量包括疼痛评分、阿片类药物用量、住院时间和术后并发症。所有数据分析均采用 STATA 13.0 进行。采用 Cochrane 协作组工具评估偏倚风险。

结果

7 项 RCT 符合纳入标准,FICB 组 165 例,安慰剂组 160 例。本荟萃分析表明,两组在术后 12 小时(WMD=-0.285,95%CI[-0.460,-0.109],P=0.002)和 24 小时(WMD=-0.391,95%CI[-0.723,-0.059],P=0.021)的疼痛评分上有显著差异。FICB 在术后 12 小时(WMD=-5.394,95%CI[-8.772,-2.016],P=0.002)和 24 小时(WMD=-6.376,95%CI[-10.737,-2.016],P=0.004)的阿片类药物用量方面优于安慰剂,有显著的优势。两组在住院时间上无显著差异(WMD=0.112,95%CI[-0.125,0.350],P=0.354)。

结论

股外侧肌间隔阻滞在全髋关节置换术后早期是有效的,可以缓解疼痛。同时,它减少了累积吗啡用量和阿片类药物相关不良反应的风险。

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