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股神经阻滞与股外侧肌间隙阻滞在膝关节和髋关节置换术中镇痛效果的比较:一项荟萃分析。

Femoral nerve block versus fascia iliaca block for pain control in knee and hip arthroplasties: A meta-analysis.

机构信息

Department of Anesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology.

Department of Orthopaedics, Chengdu First People's Hospital, China.

出版信息

Medicine (Baltimore). 2021 Apr 9;100(14):e25450. doi: 10.1097/MD.0000000000025450.

Abstract

BACKGROUND

This meta-analysis aimed to compare the efficiency of fascia iliaca compartment block (FICB) and femoral nerve block (FNB) for pain management in knee and hip surgeries.

METHODS

We searched four electronic databases (Pubmed, Embase, Cochrane library database, Web of Science) from inception to January 2019. Only randomized controlled trials (RCTs) were included. Two review authors independently extracted data for each included study. Primary outcomes were visual analogue scale at 12 hours, 24 hours, 48 hours, total morphine consumption, the length of hospital stay and the occurrence of nausea and vomiting. Standardized mean difference (SMD) or risk ratio (RR) and 95% confidence intervals (CIs) were calculated for continuous outcomes and discontinuous outcomes respectively. We used the Cochrane Risk of Bias tool to assess risk of bias. Stata 12.0 was used for meta-analysis.

RESULTS

Finally, 7 RCTs involving 508 patients (FICB = 254, FNB = 254) were included in this meta-analysis. Compared with FNB group, FICB has no benefit for visual analogue scale at 12 hours (SMD = 0.02, 95% CI, -0.15 to 0.19; P = .820), 24 hours (SMD = -0.02, 95% CI, -0.22 to 0.18; P = .806), and 48 hours (SMD = -0.02, 95% CI, -0.22 to 0.19; P = .872). No significant differences were found regarding total morphine consumption (SMD = -0.07, 95% CI, -0.29 to 0.15; P = .533). What's more, there was no significant difference between the length of hospital stay and the occurrence of nausea and vomiting (P > .05).

CONCLUSION

FICB has equivalent pain control and morphine-sparing efficacy when compared with FNB. More high-quality RCTs are needed to identify the optimal drugs and volume of local infiltration protocols.

摘要

背景

本荟萃分析旨在比较股外侧肌筋膜间隙阻滞(FICB)和股神经阻滞(FNB)在膝关节和髋关节手术中的止痛效果。

方法

我们从建库到 2019 年 1 月检索了四个电子数据库(PubMed、Embase、Cochrane 图书馆数据库、Web of Science)。仅纳入随机对照试验(RCT)。两位综述作者独立提取每个纳入研究的数据。主要结局指标为 12 小时、24 小时、48 小时的视觉模拟评分(VAS)、总吗啡消耗量、住院时间和恶心呕吐的发生情况。连续结局指标采用标准化均数差(SMD)或风险比(RR)及其 95%置信区间(CI)表示,不连续结局指标采用风险比(RR)及其 95%CI 表示。我们使用 Cochrane 偏倚风险工具评估偏倚风险。Stata 12.0 用于荟萃分析。

结果

最终,本荟萃分析纳入了 7 项 RCT 共 508 例患者(FICB 组 254 例,FNB 组 254 例)。与 FNB 组相比,FICB 在 12 小时(SMD=0.02,95%CI,-0.15 至 0.19;P=0.820)、24 小时(SMD=-0.02,95%CI,-0.22 至 0.18;P=0.806)和 48 小时(SMD=-0.02,95%CI,-0.22 至 0.19;P=0.872)的 VAS 评分方面没有获益。两组间总吗啡消耗量(SMD=-0.07,95%CI,-0.29 至 0.15;P=0.533)也无显著差异。此外,两组间住院时间和恶心呕吐的发生率无显著差异(P>0.05)。

结论

与 FNB 相比,FICB 具有等效的止痛效果和吗啡节省效果。需要更多高质量的 RCT 来确定最佳的局部浸润方案药物和容量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c771/8036080/8b092a60268a/medi-100-e25450-g001.jpg

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