Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
Fitoterapia. 2019 Apr;134:465-473. doi: 10.1016/j.fitote.2019.03.026. Epub 2019 Mar 25.
Eight new compounds named as dictamalkosides A (1), B (2), C (3), dictamphenosides A (4), B (5), C (6), D (7) and E (8), as well as 23 known ones were obtained from the 70% EtOH extract of Cortex Dictamni. Their structures were ascertained based on the spectroscopic evidences. Among the known compounds, 14, 17-23, 25-28, and 31 were isolated from Dictamnus genus for the first time; 16 and 24 were firstly isolated from this plant. And the C NMR data of 14 was reported here for the first time. Moreover, compounds 1-8, 12, 18-21, 27 and 31 were found to exhibit potential inhibitory effect on LPS-induced NO production at 40 μM for RAW 264.7 macrophages, which suggested alkaloids and phenolic acids might be anti-inflammation therapeutic substance in Cortex Dictamni.
从秦皮的 70%乙醇提取物中分离得到了 8 种新化合物，分别命名为 dictamalkosides A(1)、B(2)、C(3)、dictamphenosides A(4)、B(5)、C(6)、D(7)和 E(8)，以及 23 种已知化合物。基于光谱证据确定了它们的结构。在已知化合物中，14、17-23、25-28 和 31 是首次从瑞香科植物中分离得到的；16 和 24 是首次从该植物中分离得到的。此外，14 的 13C NMR 数据也是首次报道。此外，化合物 1-8、12、18-21、27 和 31 在 40μM 浓度下对 LPS 诱导的 RAW 264.7 巨噬细胞中 NO 的产生表现出潜在的抑制作用，这表明生物碱和酚酸可能是秦皮中的抗炎治疗物质。
