Department of Rheumatology, The Second Affiliated Hospital of Nanchang University, No.1, Minde Road, Nanchang, 330006, Jiangxi, People's Republic of China.
Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Clin Rheumatol. 2019 Aug;38(8):2053-2061. doi: 10.1007/s10067-019-04502-8. Epub 2019 Mar 28.
Rheumatoid arthritis (RA) may increase the risk of anxiety, but results from prior studies have no consensus. Our study aimed to evaluate the relationship between RA and incident anxiety by using a quantitative meta-analysis.
A number of databases were used to gather relevant information; they included PubMed, EMBASE, and Web of Science, with the publication date of articles limited up to July 23, 2018. To evaluate their association, an odds ratio (OR) with 95% confidence interval (CI) was used. The random-effects model played a crucial role in calculating the pooled odds ratio, while subgroup analyses and sensitivity analyses were also performed.
A total of 10 studies, including 6201 cases of anxiety and 139,875 participants, met our inclusion criteria for this meta-analysis. All individuals were without anxiety at baseline. The follow-up period ranged from 1.0 to 9.2 years. Overall, the quantitative meta-analysis suggested that subjects with RA were associated with a significantly increased risk of anxiety incidence (OR, 1.20; 95% CI, 1.03-1.39) than those without.
Results of this meta-analysis indicate that individuals with RA may confer an increased risk for the development of anxiety. Future studies should explore whether clinical manifestations of RA are modifiable risk factors for anxiety.
类风湿关节炎（RA）可能会增加焦虑的风险，但先前研究的结果尚无定论。我们的研究旨在通过定量荟萃分析来评估 RA 与新发焦虑之间的关系。
我们使用了多个数据库来收集相关信息，包括 PubMed、EMBASE 和 Web of Science，文章的出版日期截止到 2018 年 7 月 23 日。为了评估它们之间的关联，我们使用了优势比（OR）及其 95%置信区间（CI）。随机效应模型在计算汇总优势比方面发挥了关键作用，同时还进行了亚组分析和敏感性分析。
共有 10 项研究符合我们的荟萃分析纳入标准，包括 6201 例焦虑病例和 139875 名参与者。所有参与者在基线时均无焦虑。随访时间从 1.0 年到 9.2 年不等。总体而言，定量荟萃分析表明，与无 RA 的个体相比，RA 患者发生焦虑的风险显著增加（OR，1.20；95%CI，1.03-1.39）。
本荟萃分析的结果表明，RA 患者可能会增加发生焦虑的风险。未来的研究应探讨 RA 的临床表现是否为焦虑的可改变的危险因素。
