Baciewicz A M
Ther Drug Monit. 1986;8(3):305-17. doi: 10.1097/00007691-198609000-00012.
Carbamazepine (CBZ) is commonly prescribed as an anticonvulsant or for the pain of trigeminal neuralgia. The potential for clinically important drug interactions exists because CBZ may induce the hepatic metabolism of other drugs or, conversely, other drugs may induce or inhibit the metabolism of CBZ. Studies and case reports demonstrate that CBZ may accelerate the metabolism of phenytoin, phenobarbital (PB), primidone, valproic acid, and warfarin. Likewise, phenytoin, PB, and primidone may increase the hepatic metabolism of CBZ. Inhibition of the metabolism of CBZ has been caused by triacetyloleandomycin, erythromycin, propoxyphene, isoniazid, and cimetidine. Future investigations will document the clinical significance of the CBZ interactions as well as reveal new interactions.
卡马西平（CBZ）通常被用作抗惊厥药或用于治疗三叉神经痛。由于CBZ可能诱导其他药物的肝脏代谢，或者相反，其他药物可能诱导或抑制CBZ的代谢，因此存在具有临床重要性的药物相互作用的可能性。研究和病例报告表明，CBZ可能会加速苯妥英、苯巴比妥（PB）、扑米酮、丙戊酸和华法林的代谢。同样，苯妥英、PB和扑米酮可能会增加CBZ的肝脏代谢。三乙酰竹桃霉素、红霉素、丙氧芬、异烟肼和西咪替丁可抑制CBZ的代谢。未来的研究将记录CBZ相互作用的临床意义，并揭示新的相互作用。
