Department of Orthopedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, #88 Jie Fang Road, Hangzhou 310009, Zhejiang, P.R. China.
Orthopedics Research Institute of Zhejiang University, No. 88, Jiefang Road, Hangzhou 310009, P.R. China.
Curr Stem Cell Res Ther. 2019;14(6):495-503. doi: 10.2174/1574888X14666190329095638.
Spinal cord injury (SCI) is a devastating event, and there are still no effective therapies currently available. Neural stem cells (NSCs) have gained increasing attention as promising regenerative therapy of SCI. NSCs based therapies of various neural diseases in animal models and clinical trials have been widely investigated. In this review we aim to summarize the development and recent progress in the application of NSCs in cell transplantation therapy for SCI. After brief introduction on sequential genetic steps regulating spinal cord development in vivo, we describe current experimental approaches for neural induction of NSCs in vitro. In particular, we focus on NSCs induced from pluripotent stem cells (PSCs). Finally, we highlight recent progress on the NSCs, which show great promise in the application to regeneration therapy for SCI.
脊髓损伤（SCI）是一种毁灭性的事件，目前仍然没有有效的治疗方法。神经干细胞（NSCs）作为 SCI 的一种有前途的再生治疗方法，越来越受到关注。基于 NSCs 的各种神经疾病的治疗方法已经在动物模型和临床试验中得到了广泛的研究。在这篇综述中，我们旨在总结 NSCs 在 SCI 细胞移植治疗中的发展和最新进展。在简要介绍了体内调节脊髓发育的连续遗传步骤之后，我们描述了目前在体外对 NSCs 进行神经诱导的实验方法。特别是，我们专注于由多能干细胞（PSCs）诱导的 NSCs。最后，我们强调了 NSCs 的最新进展，这些进展在 SCI 再生治疗的应用中显示出巨大的潜力。
