Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China.
Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China.
Anal Chim Acta. 2019 Jul 11;1061:1-12. doi: 10.1016/j.aca.2019.02.045. Epub 2019 Mar 3.
It has become increasingly crucial to implement the precise determination of hydrogen sulfide (HS) in biosystems since the abnormal level of HS may induce various diseases. However, due to the high volatility and fast catabolism of HS, traditional HS detection methods are confronted with great challenges. Fortunately, the development of optical nanotechnology sheds new light on the real-time and sensitive detection of intracellular or subcellular HS. Nanomaterials emerged as potential candidates for the optical detection of biomolecule analytes due to their excellent properties, such as easy preparation and modification, tunable optical characteristics and high photostability. Recently, many probes based on nanomaterials, ranging from inorganic nanostructures to organic polymers, have been demonstrated to exhibit high sensitive and selective detection toward HS both in vitro and in vivo. Different from the previous review articles, we mainly summarize the advancements of optical probes, including fluorescence and non-fluorescence probes, for endogenous HS detection based on nanomaterials in recent five years.
由于 HS 水平异常可能导致各种疾病，因此在生物系统中精确测定 HS 变得越来越重要。然而，由于 HS 的高挥发性和快速代谢，传统的 HS 检测方法面临着巨大的挑战。幸运的是，光学纳米技术的发展为细胞内或亚细胞 HS 的实时和灵敏检测带来了新的曙光。由于具有易于制备和修饰、可调光学特性和高光稳定性等优异性能，纳米材料成为生物分子分析物光学检测的潜在候选材料。最近，许多基于纳米材料的探针，从无机纳米结构到有机聚合物，已被证明在体外和体内对 HS 具有高灵敏和选择性的检测。与以前的综述文章不同，我们主要总结了近五年来基于纳米材料的用于内源性 HS 检测的光学探针（包括荧光和非荧光探针）的进展。
