Shang Xuefang, Liu Bingqing, Liu Lixia, Wang Jia, Wang Yingling
Department of Medical Chemistry, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
J Fluoresc. 2024 May;34(3):1269-1278. doi: 10.1007/s10895-023-03374-1. Epub 2023 Aug 1.
In order to better monitor the content of Fe and HS in the biological environment, two new fluorescent probes were designed and synthesized. With the addition of Fe, the strong fluorescence emission of two probes was significantly quenched due to the paramagnetic effect of Fe. With the further addition of S, the fluorescence intensity was quickly restored. Two probes showed high selectivity and strong sensitivity for the detection of Fe and S, and the fluorescence intensity "ON-OFF-ON" was accompanied with the interaction process. At the same time, two probes displayed good anti-interference ability which was not interfered by the existence of other ions. In addition, two probes illustrated fast response time to Fe, S and small cytotoxicity to cells. Therefore, two probes can provide a potential ideal tool for detecting Fe and HS in organisms and the environment.
为了更好地监测生物环境中Fe和HS的含量，设计并合成了两种新型荧光探针。加入Fe后，由于Fe的顺磁效应，两种探针的强荧光发射显著猝灭。进一步加入S后，荧光强度迅速恢复。两种探针对Fe和S的检测具有高选择性和强灵敏度，且荧光强度“开-关-开”伴随着相互作用过程。同时，两种探针表现出良好的抗干扰能力，不受其他离子存在的干扰。此外，两种探针对Fe、S的响应时间快，对细胞的细胞毒性小。因此，两种探针可为检测生物和环境中的Fe和HS提供一种潜在的理想工具。
