Danone Nutricia Research, Singapore.
Department of Paediatrics, Allergy Service, KK Women's and Children's Hospital, Singapore.
Hum Immunol. 2019 Jul;80(7):533-536. doi: 10.1016/j.humimm.2019.03.018. Epub 2019 Mar 26.
The mode of delivery is a known risk factor for immune-related disorders. Normal term vaginal delivery is an inflammatory process and several cytokines are suggested to be involved. The purpose of the study was to evaluate differences in cord blood cytokine expression between modes of delivery in term-born children. Cord blood was collected from 49 elective Caesarean section (C-section) cases and from 49 normal vaginal term deliveries. Plasma was tested for 17 cytokines with Bio-Plex®-200-system. Mann-Whitney test was used for comparing the groups with Bonferroni correction for multiple testing. Four cytokines showed significant differences between the modes of delivery. Interleukin-6, Interleukin-8 showed a significantly higher expression in the vaginal delivery group, while Tumor-Necrosis Factor-a, Granulocyte-Colony Stimulating Factor showed a significantly higher level of expression in the C-section cord blood. Our study shows that there is differential expression of pro-inflammatory cytokines in elective C-section compared with normal term vaginal delivery.
分娩方式是与免疫相关疾病有关的已知风险因素。正常足月阴道分娩是一个炎症过程，有几种细胞因子被认为与之相关。本研究的目的是评估足月分娩的不同分娩方式对脐血细胞因子表达的影响。从 49 例择期剖宫产（C -section）病例和 49 例正常足月阴道分娩中收集脐血。使用 Bio-Plex®-200 系统检测血浆中的 17 种细胞因子。采用 Mann-Whitney 检验比较两组，采用 Bonferroni 校正进行多重检验。四种细胞因子在分娩方式之间存在显著差异。白细胞介素-6、白细胞介素-8 在阴道分娩组中的表达明显升高，而肿瘤坏死因子-α、粒细胞集落刺激因子在剖宫产组中的表达水平明显升高。我们的研究表明，与正常足月阴道分娩相比，择期剖宫产中存在促炎细胞因子的差异表达。
