健康足月儿脐带血中瘦素、白细胞介素-6和肿瘤坏死因子-α水平与分娩方式的关系
Leptin, IL-6 and TNF-α levels in umbilical cord blood of healthy term newborns in relation to mode of delivery.
作者信息
Treviño-Garza Consuelo, Villarreal-Martínez Laura, Estrada-Zúñiga Cynthia M, Leal-Treviño Mariana, Rodríguez-Balderrama Isaías, Nieto-Sanjuanero Adriana, Cárdenas-Del Castillo Bárbara, Montes-Tapia Fernando F, de la O-Cavazos Manuel
机构信息
a Department of Pediatrics and.
b Department of Gynaecology and Obstetrics , Dr. José E. González University Hospital, Universidad Autónoma De Nuevo León , Monterrey , Nuevo León , México.
出版信息
J Obstet Gynaecol. 2016 Aug;36(6):719-721. doi: 10.3109/01443615.2016.1148128. Epub 2016 Mar 25.
In the development of the foetal immune system, cytokines play an important role in its function. Therefore, we sought to determine whether the mode of delivery affects the expression of leptin, IL-6 and TNF-α in umbilical cord blood in healthy term newborns. We collected 125 samples of umbilical cord blood to analyse leptin, IL-6 y TNF-α levels with multiplex immunoassay (MIA). The samples were classified according to mode of delivery: vaginal delivery (VD) and caesarean section (CS). Leptin and IL-6 had higher concentrations in umbilical cord blood in VD than in CS: 42.55 ng/ml (11.92-104.28) versus 35.20 ng/ml (3.26-9326.76), p = 0.039; 9.32 pg/ml (1.13-2020.31) versus 3.81 pg/ml (0.52-834.69) p < 0.001, respectively. Also, a weak correlation between TNF-α and IL-6 was found (r = 0.238, p = 0.007). The most important finding in our study was the differential concentrations of leptin and IL-6 according to mode of delivery.
在胎儿免疫系统的发育过程中，细胞因子在其功能发挥中起着重要作用。因此，我们试图确定分娩方式是否会影响健康足月儿脐带血中瘦素、白细胞介素 -6（IL-6）和肿瘤坏死因子 -α（TNF-α）的表达。我们收集了125份脐带血样本，采用多重免疫测定法（MIA）分析瘦素、IL-6和TNF-α水平。样本根据分娩方式分类：阴道分娩（VD）和剖宫产（CS）。阴道分娩的脐带血中瘦素和IL-6的浓度高于剖宫产：分别为42.55 ng/ml（11.92 - 104.28）和35.20 ng/ml（3.26 - 9326.76），p = 0.039；9.32 pg/ml（1.13 - 2020.31）和3.81 pg/ml（0.52 - 834.69），p < 0.001。此外，还发现TNF-α与IL-6之间存在弱相关性（r = 0.238，p = 0.007）。我们研究中最重要的发现是根据分娩方式，瘦素和IL-6的浓度存在差异。
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