Skacel M, Knott C, Reynolds F, Aps C
Br J Anaesth. 1986 Sep;58(9):947-9. doi: 10.1093/bja/58.9.947.
Fentanyl or alfentanil, in doses approximating to those used in clinical practice, was added to the priming fluid of an extracorporeal circuit before the institution of cardiopulmonary bypass (CPB). The concentrations of both drugs in the priming fluid were measured over a 20-min period. The concentration of fentanyl decreased at neutral or high pH values, suggesting drug adsorption to the circuit. The concentration of alfentanil was unaffected. The administration of fentanyl to the priming fluid may produce lower anaesthetic concentrations than anticipated.
在建立体外循环（CPB）之前，将剂量接近临床实践中使用剂量的芬太尼或阿芬太尼添加到体外循环的预充液中。在20分钟内测量预充液中两种药物的浓度。在中性或高pH值下，芬太尼的浓度降低，表明药物吸附到体外循环装置上。阿芬太尼的浓度不受影响。向预充液中给予芬太尼可能会产生低于预期的麻醉浓度。
