核酸的光敏反应。
Photosensitized reactions of nucleic acids.
作者信息
Cadet J, Berger M, Decarroz C, Wagner J R, van Lier J E, Ginot Y M, Vigny P
出版信息
Biochimie. 1986 Jun;68(6):813-34. doi: 10.1016/s0300-9084(86)80097-9.
PMID:3092878
Abstract
The main effects of near-ultraviolet and visible light on cellular DNA are reviewed with emphasis on base lesions, oligonucleotide single-strand breaks and DNA-protein cross-links. Model system photosensitization reactions of DNA are also discussed. This includes photodynamic effects, menadione-mediated photooxidation, photoionization of antibiotics, the photochemistry of 5-halogenopyrimidines and urocanic acid.
摘要
本文综述了近紫外线和可见光对细胞DNA的主要影响，重点关注碱基损伤、寡核苷酸单链断裂和DNA-蛋白质交联。还讨论了DNA的模型系统光敏化反应。这包括光动力效应、甲萘醌介导的光氧化、抗生素的光电离、5-卤代嘧啶和尿刊酸的光化学。
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