Li Y R, Xie C J, Qiu C X, Lin Q Y, Liu Y M
Guangzhou Occupational Disease Prevention and Treatment Hospital, Guangzhou 510620, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2019 Feb 20;37(2):119-121. doi: 10.3760/cma.j.issn.1001-9391.2019.02.007.
To investigated the effect of longterm lowconcentration mixed benzene exposure on peripheral blood of male workers. A casecontrol study was conducted to select 452 male workers exposed to mixed benzene (benzene, toluene, xylene) for five consecutive years from January 2012 to December 2016 in an automobile manufacturer as case group, and 438 male administrative and logistic managers who underwent physical examination during the same period as control group. The peripheral blood of the two groups was tested and compared, and the occupational hazards in the workplace were detected. There were low dose exposure to mixed benzene in the enterprise, but the test results met the occupational exposure limit requirements. During the five years from 2010 to 2016, between the two groups of workers, the mean values of WBC, NEUT, RBC and Hb were statistically different (<0.05). There was no statistical difference (>0.05) in the mean value of PLT. The abnormal rate of main peripheral blood indexes in the control group was higher than that in the exposed group. There were significant differences in NEUT, RBC and Hb (< 0.05), but no significant differences in WBC and PLT (>0.05). It can not be concluded that longterm lowconcentration mixed benzene exposure can cause the change of peripheral blood index.
为研究长期低浓度混合苯暴露对男性工人外周血的影响。进行了一项病例对照研究,选取2012年1月至2016年12月在某汽车制造企业连续5年接触混合苯(苯、甲苯、二甲苯)的452名男性工人作为病例组,选取同期进行体检的438名男性行政和后勤管理人员作为对照组。对两组人员的外周血进行检测并比较,并检测工作场所的职业危害。企业存在混合苯低剂量暴露情况,但检测结果符合职业接触限值要求。在2010年至2016年的5年间,两组工人之间,白细胞(WBC)、中性粒细胞(NEUT)、红细胞(RBC)和血红蛋白(Hb)的均值存在统计学差异(<0.05)。血小板(PLT)均值无统计学差异(>0.05)。对照组主要外周血指标异常率高于暴露组。中性粒细胞、红细胞和血红蛋白有显著差异(<0.05),但白细胞和血小板无显著差异(>0.05)。不能得出长期低浓度混合苯暴露会导致外周血指标改变的结论。