a Neurobiology Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences , National University of Sciences and Technology , Islamabad , Pakistan.
b Department of Physical Therapy, Riphah College of Rehabilitation Sciences , Riphah International University , Islamabad , Pakistan.
Int J Neurosci. 2019 Jun;129(6):551-562. doi: 10.1080/00207454.2018.1551894.
Mild cognitive impairment (MCI) is becoming an emerging problem for developing countries where there is an increase in expected age. There is no specific curative therapeutic treatment available for these patients.
The objective of this study was to evaluate short and long-term changes in the electroencephalogram (EEG) parameters and cognition of MCI patients with aerobic exercises.
A randomized controlled trial was conducted on 40 patients which were randomly divided into two groups, 'aerobic exercise treatment group (n = 21)' and 'no-aerobic control group (n = 19)'. Short-term effects of exercise were measured after single session of exercise and long-term effects were measured after an 18 sessions (6 weeks) treatment. The outcomes which were measured were, electroenphelogram paramaters (slowness and complexity of the EEG) and cognitive functions (using mini-mental state examination (MMSE), Montreal cognitive assessment (MoCA), and trail making test (TMT) A and B).
After one session of aerobic exercise there were significant improvements in slowness (delta waves; 0.678 ± 0.035 vs 0.791 ± 0.033; p = .015) and complexity (0.601 ± 0.051 vs 0.470 ± 0.042; p = .027) of the EEG in aerobic exercise treated group as compared to no-aerobic exercise group. After six weeks there were significant improvements in slowness (delta waves; 0.581 ± 0.036 vs 0.815 ± 0.025; p = .005) and complexity (0.751 ± 0.045 vs 0.533 ± 0.046; p = .001) of the EEG in the aerobic group as compared to no-aerobic group. Moreover, significant improvements were observed in the MMSE (p = .032), MoCA (p = .036), TMT-A (p = .005), and TMT-B (p = .007) in aerobic exercise group as compared to no-aerobic group.
Aerobic exercise showed improvement in cognition after short and long-term treatment in MCI subjects and can be used as potential therapeutic candidate.
轻度认知障碍（MCI）在预期寿命增加的发展中国家正成为一个日益严重的问题。目前，针对这些患者尚无特效的治疗方法。
本研究旨在评估有氧运动对 MCI 患者脑电图（EEG）参数和认知功能的短期和长期变化。
对 40 例患者进行了一项随机对照试验，将患者随机分为两组：“有氧运动治疗组（n=21）”和“无有氧运动对照组（n=19）”。单次运动后测量短期运动效果，18 次（6 周）运动后测量长期运动效果。测量的结果包括脑电图参数（慢波和 EEG 复杂度）和认知功能（使用简易精神状态检查（MMSE）、蒙特利尔认知评估（MoCA）和连线测试（TMT）A 和 B）。
有氧运动后，与无有氧运动组相比，有氧运动治疗组的脑电图慢波（δ 波；0.678±0.035 与 0.791±0.033；p=0.015）和复杂度（0.601±0.051 与 0.470±0.042；p=0.027）均有显著改善。6 周后，与无有氧运动组相比，有氧运动组脑电图慢波（δ 波；0.581±0.036 与 0.815±0.025；p=0.005）和复杂度（0.751±0.045 与 0.533±0.046；p=0.001）也有显著改善。此外，与无有氧运动组相比，有氧运动组 MMSE（p=0.032）、MoCA（p=0.036）、TMT-A（p=0.005）和 TMT-B（p=0.007）的评分也有显著改善。
有氧运动可改善 MCI 患者短期和长期治疗后的认知功能，可作为潜在的治疗候选方法。
