Ribeiro Isadora C, Teixeira Camila V L, de Resende Thiago J R, de Campos Brunno M, Silva Gabriel B, Uchida Marco C, Magalhães Thamires N C, Pimentel-Silva Luciana R, Aventurato Ítalo K, Gonçalves Brenda C, da Silva Marjorie C R, Rizzi Liara, Fernandes Gustavo B P, Fernandes Paula T, Cendes Fernando, Balthazar Marcio L F
Laboratory of Imaging and Biomarkers in Cognitive Disorders, School of Medical Sciences, Universidade Estadual de Campinas, Campinas, Brazil.
Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
Geroscience. 2025 Jan 2. doi: 10.1007/s11357-024-01483-8.
Mild cognitive impairment (MCI) refers to cognitive alterations with preservation of functionality. Individuals with this diagnosis have a higher risk of developing dementia. Non-pharmacological interventions, such as physical exercise, are beneficial for the cognition of this population. However, the impact of resistance training (RT) on the brain anatomy of older adults with MCI has not yet been clarified. This study aimed to investigate the effects of RT on cognition and brain anatomy in MCI. Forty-four older adults with MCI, 22 in the training group and 22 in the control group, were evaluated in neuropsychological tests and magnetic resonance imaging at the beginning and end of the study, which lasted 24 weeks. We used repeated measures ANOVA. The training group showed better performance in verbal episodic memory after intervention. The control group showed a decrease in gray matter volume in the hippocampus and precuneus, while the training group showed no reduction in the right hippocampus and precuneus. However, it showed a decrease in the volume of these regions on the left side and in the left superior frontal gyrus. In the analysis of white matter integrity, fractional anisotropy increased in the training group and decreased in the control group. Axial diffusivity decreased in the training group, while radial diffusivity increased in the control group, and mean diffusivity varied according to the tract evaluated. RT improves memory performance, positively influences white matter integrity parameters, and plays a protective role against atrophy of the hippocampus and precuneus in MCI.
轻度认知障碍（MCI）是指认知功能改变但功能仍得以保留。患有这种诊断的个体患痴呆症的风险更高。非药物干预措施，如体育锻炼，对该人群的认知有益。然而，抗阻训练（RT）对患有MCI的老年人脑解剖结构的影响尚未明确。本研究旨在调查RT对MCI患者认知和脑解剖结构的影响。44名患有MCI的老年人，22名在训练组，22名在对照组，在为期24周的研究开始和结束时接受了神经心理学测试和磁共振成像评估。我们使用重复测量方差分析。训练组在干预后言语情景记忆方面表现更好。对照组海马体和楔前叶灰质体积减少，而训练组右侧海马体和楔前叶没有减少。然而，左侧这些区域以及左侧额上回的体积有所减少。在白质完整性分析中，训练组分数各向异性增加，对照组减少。训练组轴向扩散率降低，而对照组径向扩散率增加，平均扩散率根据所评估的神经束而有所不同。抗阻训练可改善记忆表现，对白质完整性参数产生积极影响，并对MCI患者海马体和楔前叶萎缩起到保护作用。
