Rapp R S, Campbell R W, Howell J C, Kendig E L
Am Rev Respir Dis. 1978 Oct;118(4):794-6. doi: 10.1164/arrd.1978.118.4.794.
One hundred sixteen children, including 50 less than 10 years of age, received isoniazid therapy for tuberculous infection. Determinations of serum glutamic oxaloacetic transaminase concentrations at time of institution of therapy, 6 to 20 weeks later, and again at the completion of the therapeutic course, showed no evidence of hepatotoxicity. Clinical symptoms were never such that discontinuation of therapy was necessary.
116名儿童，包括50名10岁以下儿童，接受了异烟肼治疗结核感染。在开始治疗时、6至20周后以及治疗疗程结束时测定血清谷氨酸草酰乙酸转氨酶浓度，未发现肝毒性证据。临床症状从未严重到需要停止治疗的程度。
