Stein M T, Liang D
Pediatrics. 1979 Oct;64(4):499-505.
A patient is presented with reversible clinical and biochemical hepatocellular injury secondary to isoniazid (INH). This apparently rare drug reaction in children is compared with the more common transient hypertransaminasemia induced by isoniazid. A review of the clinical literature and basic pharmacologic mechanisms of isoniazid-induced hepatotoxicity has led to a rational plan for monitoring and managing children who are treated with INH.
一名患者出现了继发于异烟肼（INH）的可逆性临床和生化肝细胞损伤。将这种在儿童中明显罕见的药物反应与异烟肼诱导的更常见的短暂性高转氨酶血症进行了比较。对异烟肼诱导肝毒性的临床文献和基本药理机制进行回顾后，得出了一个监测和管理接受INH治疗儿童的合理方案。
