Larsen V H, Fabricius J, Nielsen G, Hansen K S
Br Med J (Clin Res Ed). 1986 Sep 13;293(6548):650-2. doi: 10.1136/bmj.293.6548.650.
The specific serotonin receptor blocker ketanserin was given orally to 12 patients with traumatic vasospastic disease in a double blind crossover study. The effect of treatment was assessed by measuring finger systolic pressure and rewarming time after cold provocation and by medical interview and diaries. Median (range) percentage change in finger systolic pressure after cooling was 50 (0-100)% after treatment with ketanserin compared with 0 (0-90)% after placebo. Median (range) rewarming time after cooling decreased from 320 (236-972)s with placebo to 160 (88-404)s after treatment with ketanserin. These changes were not significant. Ninety five percent confidence intervals for difference between the treatments, however, showed that finger systolic pressure may be 80% better and rewarming time 256 seconds faster after treatment with ketanserin than after placebo. The number of attacks did not differ significantly between the two treatments. Two patients had a feeling of warmth in their hands during treatment with ketanserin. The results suggest that orally administered ketanserin may improve digital circulation in patients with traumatic vasospastic disease, but larger numbers of patients are required to assess the true effect of treatment with ketanserin in this disease.
在一项双盲交叉研究中，对12名创伤性血管痉挛疾病患者口服特异性血清素受体阻滞剂酮色林。通过测量冷刺激后的手指收缩压和复温时间、医学访谈及日记来评估治疗效果。与服用安慰剂后相比，服用酮色林后冷却后手指收缩压的中位数（范围）变化百分比为50（0 - 100）%，而服用安慰剂后为0（0 - 90）%。冷却后的复温时间中位数（范围）从服用安慰剂后的320（236 - 972）秒降至服用酮色林后的160（88 - 404）秒。这些变化无显著意义。然而，两种治疗之间差异的95%置信区间显示，服用酮色林后手指收缩压可能比服用安慰剂后改善80%，复温时间快256秒。两种治疗之间发作次数无显著差异。两名患者在服用酮色林治疗期间手部有温暖感。结果表明，口服酮色林可能改善创伤性血管痉挛疾病患者的手指血液循环，但需要更多患者来评估酮色林治疗该疾病的真实效果。
