van de Wal H J, Wijn P F, van Lier H J, Skotnicki S H
Department Thoracic, Cardiac and Vascular Surgery, Sint Radboud University Hospital, Nijmegen, The Netherlands.
Int Angiol. 1987 Jul-Sep;6(3):313-22.
In 41 patients with Primary Raynaud's Phenomenon (PRP) the effectiveness of the serotonin receptor blocker ketanserin has been studied in a double blind cross-over study. Subjective assessments included: frequency and duration of the attacks (both per se and combined to a severity score), cold sensation, numbness, paresthesia, pain, cold water and cold weather provocation and the appearance of spontaneous attacks. The objective measurements comprised Digital Skin Temperature (DST), Digital systolic Blood Pressure (DBP) and Doppler Spectral Analysis (DOSA) of the radial and ulnar arteries. All measurements were performed both at room temperature and after instant cold provocation. The severity score, the occurrence of numbness and paresthesia and cold weather provocation improved significantly on ketanserin treatment. All objective measurements with the exception of the end-diastolic blood flow velocity of DOSA did not show significant improvements. Neither blood chemistry nor systemic blood pressure showed any significant change during ketanserin treatment. However, in the 6 (15%) patients with hypertension both systolic and diastolic blood pressure normalized. Although in objective measurements hardly any significant effects of ketanserin could be demonstrated, the results of the study suggest that orally administered ketanserin is effective for minimizing subjective complaints in patients with PRP. Ketanserin did not show any side effects.
在一项双盲交叉研究中,对41例原发性雷诺现象(PRP)患者使用血清素受体阻滞剂酮色林的疗效进行了研究。主观评估包括:发作频率和持续时间(单独以及合并为严重程度评分)、冷感、麻木、感觉异常、疼痛、冷水和寒冷天气激发试验以及自发发作的出现情况。客观测量包括手指皮肤温度(DST)、手指收缩压(DBP)以及桡动脉和尺动脉的多普勒频谱分析(DOSA)。所有测量均在室温下以及即时冷激发试验后进行。使用酮色林治疗后,严重程度评分、麻木和感觉异常的发生率以及寒冷天气激发试验结果均有显著改善。除了DOSA的舒张末期血流速度外,所有客观测量指标均未显示出显著改善。在酮色林治疗期间,血液化学指标和全身血压均未出现任何显著变化。然而,6例(15%)高血压患者的收缩压和舒张压均恢复正常。尽管在客观测量中几乎未显示出酮色林有任何显著效果,但该研究结果表明,口服酮色林对减轻PRP患者的主观症状有效。酮色林未显示出任何副作用。