Borragán Guillermo, Guerrero-Mosquera Carlos, Guillaume Céline, Slama Hichem, Peigneux Philippe
UR2NF - Neuropsychology and Functional Neuroimaging, CRCN - Centre de Recherches en Cognition et Neurosciences and UNI - ULB Neurosciences Institute, Université Libre de Bruxelles (ULB), Belgium.
UPF - Universitat Pompeu Fabra, Center of Brain and Cognition (CBC), Spain.
Biol Psychol. 2019 May;144:115-124. doi: 10.1016/j.biopsycho.2019.03.004. Epub 2019 Mar 28.
Fatigue induced by sustained cognitive demands often entails decreased behavioural performance and the unavailability of brain resources, either due to reduced levels or impaired access. In the present study, we investigated the neural dynamics underlying preserved behavioural performance after inducing cognitive fatigue (CF) in a sleep deprivation (SD) condition in which resources are naturally compromised. Using functional near infrared spectroscopy (fNIRS), we recorded cortical brain activity during task-related CF induction in the evening, in the middle of the night and early in the morning. Although cortical oxygenation similarly increased over the 3 sessions, decreased intra-hemispheric connectivity between left anterior frontal and frontal areas paralleled a sudden drop in task performance in the early morning. Our data indicate that decreased sustained attention after the induction of cognitive fatigue in a situation of high sleep pressure results from impaired connectivity between left prefrontal cortical areas rather than from a mere modulation in brain resources.
持续认知需求所诱发的疲劳常导致行为表现下降和大脑资源无法有效利用，这要么是由于水平降低，要么是由于获取受损。在本研究中，我们调查了在睡眠剥夺（SD）条件下诱发认知疲劳（CF）后行为表现得以保留的神经动力学，在这种条件下资源自然会受到损害。我们使用功能近红外光谱技术（fNIRS），在傍晚、午夜和清晨与任务相关的CF诱发过程中记录皮质脑活动。尽管在这三个时间段皮质氧合同样增加，但左前额叶前部与额叶区域之间半球内连接性的降低与清晨任务表现的突然下降同时出现。我们的数据表明，在高睡眠压力情况下诱发认知疲劳后持续注意力下降是由于左前额叶皮质区域之间连接性受损，而非仅仅是大脑资源的调节。
