[阿尔茨海默病与人类白细胞抗原系统之间不存在连锁关系]
[Absence of linkage between Alzheimer's disease and the HLA system].
作者信息
Muller J Y, Clémenceau S, Foncin J F, Salmon D, Hallé L, Castellano F, Salmon C
出版信息
C R Acad Sci III. 1986;303(4):105-8.
The study of a family in which multiple cases of Alzheimer's disease occurred in several generations offers the opportunity to test the genetic transmission of this disease. The HLA grouping of the members of a pedigree containing 10 affected members allowed to demonstrate that the disease is not due to a single dominant gene linked to the major histocompatibility complex. Although a more complex involvement of the major histocompatibility complex cannot be totally ruled out it is obvious that a strong linkage does not exist between Alzheimer's disease and HLA.
对一个几代人中出现多例阿尔茨海默病的家族进行研究，为测试这种疾病的基因传递提供了机会。对一个包含10名患病成员的家系成员进行HLA分型，结果表明该疾病并非由与主要组织相容性复合体相关的单一显性基因所致。虽然不能完全排除主要组织相容性复合体存在更复杂的关联，但很明显阿尔茨海默病与HLA之间不存在强关联。
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