[家族性阿尔茨海默病：HLA标记物研究]
[Familial Alzheimer's disease: a study of HLA markers].
作者信息
Delasnerie-Lauprêtre N, Calot M, Ohayon E, Foucault C, Cambon-de-Mouzon A, Clanet M, Cathala F
出版信息
Biomed Pharmacother. 1983;37(4):186-8.
PMID:6581838
Abstract
We have studied HLA markers in family with 2 "Probable" and 2 "possible" cases of Alzheimer disease over 3 generations. Three of them (two brothers and the father) present A29 C-B12 DR2 haplotype. It seems that it exists an association between HLA system and Alzheimer disease but we cannot define the character of this genetic linkage; the study of many families and sporadic cases will allow to define it.
摘要
我们研究了一个三代家族中的HLA标记，该家族中有2例“可能”和2例“疑似”阿尔茨海默病患者。其中三人（两兄弟和父亲）呈现A29 C-B12 DR2单倍型。似乎HLA系统与阿尔茨海默病之间存在关联，但我们无法确定这种基因连锁的性质；对更多家族和散发病例的研究将有助于确定这一点。
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