University of North Florida, Jacksonville, Florida.
University of North Florida, Jacksonville, Florida.
J Card Fail. 2019 Jun;25(6):418-424. doi: 10.1016/j.cardfail.2019.03.017. Epub 2019 Mar 28.
This study examined the relationship between self-reported sedentary time (ST) and the cumulative risk of heart failure with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF) in a diverse cohort of U.S. adults 45-84 years of age.
Using data from the Multi-Ethnic Study of Atherosclerosis (MESA), we identified 6,814 subjects, all free of baseline cardiovascular disease. Cox regression was used to calculate the hazard ratios (HR) associated with risk of HFpEF and HFrEF. Weekly ST was dichotomized based on the 75th percentile (1890 min/wk). During ∼11.2 years of follow-up there were 178 first incident HF diagnoses: 74 HFpEF and 69 HFrEF. Baseline ST >1890 min/wk was significantly associated with an increased risk of HFpEF (HR 1.87, 95% confidence interval [CI] 1.13-3.09, P = .01), but not of HFrEF. The relationship with HFpEF remained significant in fully adjusted models including physical activity and waist circumference (HR 2.16, 95% CI 1.23-3.78, P < .01). In addition, every 60-minute increase in weekly ST was associated with a 3% increased risk of HFpEF (HR 1.03, 95% CI 1.01-1.05, P < .01).
Sedentary time >1890 min/wk (∼4.5 h/d) is a significant predictor of HFpEF, independently from physical activity and adiposity.
本研究在美国 45-84 岁的多种族成年人队列中，考察了自我报告的久坐时间（ST）与射血分数保留型心力衰竭（HFpEF）和射血分数降低型心力衰竭（HFrEF）累积风险之间的关系。
利用动脉粥样硬化多民族研究（MESA）的数据，我们确定了 6814 名无基线心血管疾病的受试者。使用 Cox 回归计算与 HFpEF 和 HFrEF 风险相关的风险比（HR）。每周 ST 根据第 75 百分位数（1890 分钟/周）分为两部分。在大约 11.2 年的随访期间，发生了 178 例首次 HF 诊断：74 例 HFpEF 和 69 例 HFrEF。基线 ST >1890 分钟/周与 HFpEF 的风险增加显著相关（HR 1.87，95%置信区间 [CI] 1.13-3.09，P =.01），但与 HFrEF 无关。在包括体力活动和腰围在内的完全调整模型中，这种与 HFpEF 的关系仍然显著（HR 2.16，95% CI 1.23-3.78，P <.01）。此外，每周 ST 增加 60 分钟与 HFpEF 的风险增加 3%相关（HR 1.03，95% CI 1.01-1.05，P <.01）。
久坐时间>1890 分钟/周（约 4.5 小时/天）是 HFpEF 的一个重要预测指标，独立于体力活动和肥胖程度。
