Department of Zoology, University of British Columbia, #4200-6270 University Blvd., Vancouver, B.C, V6T 1Z4, Canada.
Department of Biology and Centre for Forest Interdisciplinary Research, University of Winnipeg, 515 Portage Avenue, Winnipeg, MB, R3B 2E9, Canada.
Respir Physiol Neurobiol. 2019 Jun;264:19-27. doi: 10.1016/j.resp.2019.03.006. Epub 2019 Mar 29.
Burrowing rodents have a blunted ventilatory response to CO in comparison to non-burrowing rodents. Non-burrowing rats display a period during development where ventilatory responses to hypercarbia become transiently blunted. This study examined the ventilatory responses to CO of rats, hamsters and ground squirrels through neonatal development to determine whether the blunted adult response of burrowing species is a retention of the blunting period seen in rats or present from birth. All three species increased ventilation in response to hypercarbia on the day of birth (70-170% in response to 5% CO; 100-250% in response to 7% CO). Rats in our study exhibited the triphasic ventilatory response (when expressed as %Δ) to CO previously described. In golden-Syrian hamsters, the ventilatory response slowly and progressively waned to a blunted adult response while in the 13-lined ground squirrels, the early ventilatory response to CO decreased within days and remained attenuated through development. Our study shows three distinct developmental patterns in the hypercarbic ventilatory response.
穴居啮齿动物的通气反应比非穴居啮齿动物迟钝。非穴居大鼠在发育过程中会出现一段时间，其对高碳酸血症的通气反应会暂时减弱。本研究通过新生儿发育来研究大鼠、仓鼠和地松鼠对 CO 的通气反应，以确定穴居物种的成年反应迟钝是否是对大鼠所见的迟钝期的保留，或者是否从出生起就存在。所有三种物种在出生当天都会增加通气以应对高碳酸血症（5% CO 时增加 70-170%；7% CO 时增加 100-250%）。本研究中的大鼠表现出先前描述的 CO 的三相通气反应（当以%Δ表示时）。在金黄仓鼠中，通气反应缓慢而逐渐减弱至成人反应迟钝，而在 13 线地松鼠中，对 CO 的早期通气反应在数天内下降，并在发育过程中持续减弱。我们的研究显示了三种不同的高碳酸血症通气反应的发育模式。
