Department of Chemistry, College of Sciences, Taibah University, Al-Medina Al-Munawara 41477, Saudi Arabia; Department of Chemistry, Jamia Millia Islamia (Central University), New Delhi 110025, India.
Department of Biology, College of Sciences, Taibah University, Al-Medina Al-Munawara 41477, Saudi Arabia.
Int J Biol Macromol. 2019 Jul 1;132:244-253. doi: 10.1016/j.ijbiomac.2019.03.211. Epub 2019 Mar 28.
Many water bodies are being contaminated by atorvastatin, which has certain side effects and problems on healthy individuals through contaminated water. For this purpose, effective and selective carboxymethylcellulose macromolecule iron composite nanoparticles were synthesized by green methods, characterized and used for uptake of atorvastatin drug residue from water. Atorvastatin in water was analyzed by HPLC using Aqua C (250 mm × 46 mm id) column and buffer-ACN (35:65, v/v) as eluent. The maximum elimination of atorvastatin was 80% with 40 μg L concentration; 40 min agitated time, 5.0 pH, 1.0 g L dose and 298 K temp. The removal data obeyed Freundlich, Langmuir, Dubinin-Radushkevich and Temkin models. The values of free energy were -8.79, -8.73 and -8.65 kJ mol at 20.0, 25.0 and 30.0 °C temperatures. Enthalpy value was -14.16 kJ mol; showing exothermic removal. Entropy was -18.74 × 10 kJ mol K; presenting decrease in entropy in the process. The kinetics modeling showed pseudo-first-order and liquid film diffusion mechanisms of removal. The removal technology was quick, conservation pleasant and lucrative. It is because of it capability with little dose and interaction time. Hence, the reported technology is practical for the exclusion of atorvastatin in water resource.
许多水体受到阿托伐他汀的污染，通过受污染的水，阿托伐他汀对健康个体有一定的副作用和问题。为此，采用绿色方法合成了有效且选择性的羧甲基纤维素大分子铁复合纳米粒子，并对其进行了表征，用于从水中摄取阿托伐他汀药物残留。采用 HPLC 法，以 Aqua C（250mm×46mm id）柱和缓冲液-乙腈（35:65，v/v）为洗脱液，对水中的阿托伐他汀进行分析。在 40μg/L 浓度下，最大消除率为 80%，搅拌时间为 40min，pH 值为 5.0，剂量为 1.0g/L，温度为 298K。去除数据符合 Freundlich、Langmuir、Dubinin-Radushkevich 和 Temkin 模型。在 20.0、25.0 和 30.0°C 温度下，自由能值分别为-8.79、-8.73 和-8.65kJ/mol。焓值为-14.16kJ/mol，表明去除是放热的。熵值为-18.74×10kJ/mol/K，表明过程中熵减小。动力学模型表明去除过程符合准一级动力学和液膜扩散机制。去除技术快速、环保且有利可图。这是因为它具有剂量小、相互作用时间短的特点。因此，所报道的技术对于排除水资源中的阿托伐他汀是实用的。
