Carroll S B, Laymon R A, McCutcheon M A, Riley P D, Scott M P
Cell. 1986 Oct 10;47(1):113-22. doi: 10.1016/0092-8674(86)90372-7.
The homeotic Antennapedia (Antp) gene of Drosophila is required for the normal differentiation of the thoracic segments during embryonic development and metamorphosis. Antibodies to a recombinant Antp protein were used to localize the protein in whole mount embryos. Antp is expressed in the nuclei of cells of the thoracic embryonic epidermis and several segments of the ventral and peripheral nervous systems. Analysis of Antp expression in mutant embryos revealed three levels of Antp regulation by genes of the bithorax complex, pleiotropic homeotic loci, and Antp itself. The distributions of the Antp and the Ultrabithorax (Ubx) proteins in doubly-labeled embryos suggest that the Ubx protein may be one direct negative regulator of Antp gene expression.
果蝇的同源异型基因触角足基因（Antp）在胚胎发育和变态过程中，对于胸节的正常分化是必需的。针对重组Antp蛋白的抗体被用于在完整胚胎中定位该蛋白。Antp在胸胚胎表皮细胞以及腹侧和外周神经系统的几个节段的细胞核中表达。对突变胚胎中Antp表达的分析揭示了由双胸复合体基因、多效同源异型位点和Antp自身对Antp进行调控的三个层次。在双重标记胚胎中Antp和超双胸（Ubx）蛋白的分布表明，Ubx蛋白可能是Antp基因表达的一个直接负调控因子。
