母体和新生儿维生素D与儿童牙齿发育的关联
The Associations of Maternal and Neonatal Vitamin D with Dental Development in Childhood.
作者信息
Dhamo Brunilda, Miliku Kozeta, Voortman Trudy, Tiemeier Henning, Jaddoe Vincent Wv, Wolvius Eppo B, Ongkosuwito Edwin M
机构信息
Department of Oral & Maxillofacial Surgery, Special Dental Care and Orthodontics.
The Generation R Study Group.
出版信息
Curr Dev Nutr. 2019 Mar 7;3(4):nzy100. doi: 10.1093/cdn/nzy100. eCollection 2019 Apr.
BACKGROUND
Vitamin D influences the formation and mineralization of teeth.
OBJECTIVE
To investigate the association of maternal and neonatal vitamin D concentrations with the dental development of 10-y-old children, in a population-based prospective cohort study among 3,770 mothers and children in the Netherlands.
METHODS
Maternal venous blood samples were collected in the second trimester (median 20.4 weeks of gestation; range: 18.5-23.2 wk) whereas umbilical cord blood samples were collected immediately after delivery (median 40.1 weeks of gestation; range 35.9-42.3 wk). Dental development was defined using the Demirjian method. Multivariate regression models were built to analyze the studied associations.
RESULTS
High concentrations of 25-hydroxyvitamin D [25(OH)D] during midpregnancy (β: -0.04; 95% CI: -0.08, -0.01) and at birth (β: -0.06; 95% CI: -0.10, -0.02) were associated with a lower dental age in children. The children of mothers with severe vitamin D deficiency [25(OH)D <25.0 nmol/L] during midpregnancy exhibited a higher dental age (β: 0.14; 95% CI: 0.03, 0.24) and higher developmental stages of the mandibular first premolar (β: 0.32; 95% CI: 0.04, 0.60) compared with the children of mothers with optimal values of 25(OH)D (≥75.0 nmol/L). Children with vitamin D deficiency [25(OH)D 25.0-49.9 nmol/L] at birth exhibited a higher dental age (β: 0.11; 95% CI: 0.01, 0.20), higher developmental stages of the mandibular second premolar (β: 0.27; 95% CI: 0.02, 0.51), and higher developmental stages of the mandibular second molar (β: 0.24; 95% CI: 0.00, 0.48) compared with children with sufficient-to-optimal values of 25(OH)D (≥50.0 nmol/L) at birth.
CONCLUSION
Higher maternal and neonatal 25(OH)D concentrations are associated with decelerated dental development in childhood. The lower the vitamin D level during midpregnancy or at birth, the higher the dental age of children, and the higher the developmental stages of the mandibular teeth.
背景
维生素D影响牙齿的形成和矿化。
目的
在荷兰一项基于人群的前瞻性队列研究中，调查3770名母亲和儿童中，母亲及新生儿维生素D浓度与10岁儿童牙齿发育的关联。
方法
在孕中期（妊娠中位数20.4周；范围：18.5 - 23.2周）采集母亲静脉血样本，而在分娩后立即采集脐带血样本（妊娠中位数40.1周；范围35.9 - 42.3周）。使用德米尔坚方法定义牙齿发育情况。构建多变量回归模型以分析所研究的关联。
结果
孕中期（β：-0.04；95%置信区间：-0.08，-0.01）和出生时（β：-0.06；95%置信区间：-0.10，-0.02）25-羟基维生素D[25(OH)D]浓度高与儿童牙齿年龄较低相关。与25(OH)D值最佳（≥75.0 nmol/L）的母亲所生儿童相比，孕中期母亲维生素D严重缺乏[25(OH)D<25.0 nmol/L]的儿童牙齿年龄较高（β：0.14；95%置信区间：0.03，0.24），下颌第一前磨牙发育阶段较高（β：0.32；95%置信区间：0.04，0.60）。与出生时25(OH)D值充足至最佳（≥50.0 nmol/L）的儿童相比，出生时维生素D缺乏[25(OH)D 25.0 - 49.9 nmol/L]的儿童牙齿年龄较高（β：0.11；95%置信区间：0.01，0.20），下颌第二前磨牙发育阶段较高（β：0.27；95%置信区间：0.02，0.51），下颌第二磨牙发育阶段较高（β：0.24；95%置信区间：0.00，0.48）。
结论
母亲和新生儿较高的25(OH)D浓度与儿童期牙齿发育减缓相关。孕中期或出生时维生素D水平越低，儿童牙齿年龄越高，下颌牙齿发育阶段越高。
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