安替比林清除率及代谢物形成：肝脏体积与吸烟的影响

Antipyrine clearance and metabolite formation: the influence of liver volume and smoking.

作者信息

Spoelstra P, Teunissen M W, Janssens A R, Weeda B, van Duijn W, Koch C W, Breimer D D

出版信息

Eur J Clin Invest. 1986 Aug;16(4):321-7. doi: 10.1111/j.1365-2362.1986.tb01349.x.

DOI:10.1111/j.1365-2362.1986.tb01349.x

Abstract

The influence of liver volume and cigarette smoking on antipyrine clearance and metabolite formation was studied in seventeen volunteers (eight smokers, nine non-smokers). Inter-test coefficient of variation of liver volume (as determined by ultrasound) was 6.3%. The mean antipyrine clearance was 49.3 +/- 18.3 ml min-1 and when normalized for liver volume 36.1 +/- 10.1 ml min-1 l-1. The antipyrine clearance per unit volume of liver was significantly higher in smokers (43.0 +/- 10.5 ml min-1 l-1), than in non-smokers (30.0 +/- 4.6 ml min-1 l-1) (P less than 0.01). No significant difference was found between the two groups as to the excreted amounts of 4-hydroxyantipyrine (OHA), norantipyrine (NORA), and 3-hydroxymethylantipyrine (HMA). Normalized for liver volume the mean clearances for production (Clm) of these metabolites were significantly higher in the group of smokers than in the group of non-smokers. The greatest change was observed for OHA formation. However, analysis of variance showed that the differences in the percentages of change of the mean Clm of these metabolites in the two groups are not significant.

摘要

在17名志愿者（8名吸烟者，9名非吸烟者）中研究了肝脏体积和吸烟对安替比林清除率及代谢物形成的影响。肝脏体积的测试间变异系数（通过超声测定）为6.3%。安替比林的平均清除率为49.3±18.3 ml·min⁻¹，以肝脏体积标准化后为36.1±10.1 ml·min⁻¹·l⁻¹。吸烟者每单位肝脏体积的安替比林清除率（43.0±10.5 ml·min⁻¹·l⁻¹）显著高于非吸烟者（30.0±4.6 ml·min⁻¹·l⁻¹）（P<0.01）。两组在4-羟基安替比林（OHA）、去甲安替比林（NORA）和3-羟甲基安替比林（HMA）的排泄量方面未发现显著差异。以肝脏体积标准化后，这些代谢物生成的平均清除率（Clm）在吸烟者组显著高于非吸烟者组。在OHA形成方面观察到最大变化。然而，方差分析表明两组中这些代谢物平均Clm变化百分比的差异不显著。