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DNA hypermethylation within TERT promoter upregulates TERT expression in cancer.端粒酶逆转录酶（TERT）启动子区域的DNA高甲基化可上调癌症中的TERT表达。
J Clin Invest. 2019 Apr 1;129(4):1801. doi: 10.1172/JCI128527.
2
Combined genetic and epigenetic alterations of the TERT promoter affect clinical and biological behavior of bladder cancer.TERT 启动子的联合遗传和表观遗传改变影响膀胱癌的临床和生物学行为。
Int J Cancer. 2019 Apr 1;144(7):1676-1684. doi: 10.1002/ijc.31935. Epub 2018 Dec 30.
3
Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study.TERT 启动子甲基化与儿童脑肿瘤的风险分层：一项综合基因组学和分子研究。
Lancet Oncol. 2013 May;14(6):534-42. doi: 10.1016/S1470-2045(13)70110-4. Epub 2013 Apr 16.
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TERT promoter hypermethylation is associated with poor prognosis in adrenocortical carcinoma.TERT 启动子甲基化与肾上腺皮质癌的预后不良相关。
Int J Mol Med. 2018 Sep;42(3):1675-1683. doi: 10.3892/ijmm.2018.3735. Epub 2018 Jun 20.
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aberrancies: a screening tool for malignancy in follicular thyroid tumours.异常：滤泡性甲状腺肿瘤恶性肿瘤的筛查工具。
Endocr Relat Cancer. 2018 Jul;25(7):723-733. doi: 10.1530/ERC-18-0050. Epub 2018 Apr 24.
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Differential TERT promoter methylation and response to 5-aza-2'-deoxycytidine in acute myeloid leukemia cell lines: TERT expression, telomerase activity, telomere length, and cell death.急性髓系白血病细胞系中 TERT 启动子甲基化的差异与 5-氮杂-2'-脱氧胞苷的反应：TERT 表达、端粒酶活性、端粒长度和细胞死亡。
Genes Chromosomes Cancer. 2012 Aug;51(8):768-80. doi: 10.1002/gcc.21962. Epub 2012 Apr 19.
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DNA hypermethylation enhanced telomerase reverse transcriptase expression in human-induced pluripotent stem cells.DNA 超甲基化增强人诱导多能干细胞中端粒酶逆转录酶的表达。
Hum Cell. 2018 Jan;31(1):78-86. doi: 10.1007/s13577-017-0190-x. Epub 2017 Nov 4.
8
Genetic and Epigenetic Alterations of TERT Are Associated with Inferior Outcome in Adolescent and Young Adult Patients with Melanoma.TERT 的遗传和表观遗传改变与青少年和年轻成年黑色素瘤患者的不良预后相关。
Sci Rep. 2017 Apr 5;7:45704. doi: 10.1038/srep45704.
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Tianshengyuan-1 (TSY-1) regulates cellular Telomerase activity by methylation of TERT promoter.天圣源-1（TSY-1）通过端粒酶逆转录酶（TERT）启动子的甲基化来调节细胞端粒酶活性。
Oncotarget. 2017 Jan 31;8(5):7977-7988. doi: 10.18632/oncotarget.13939.
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The TERT promoter SNP rs2853669 decreases E2F1 transcription factor binding and increases mortality and recurrence risks in liver cancer.端粒酶逆转录酶（TERT）启动子单核苷酸多态性rs2853669降低E2F1转录因子结合，并增加肝癌的死亡率和复发风险。
Oncotarget. 2016 Jan 5;7(1):684-99. doi: 10.18632/oncotarget.6331.

引用本文的文献

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The role of aberrant DNA methylation in cancer initiation and clinical impacts.异常DNA甲基化在癌症发生及临床影响中的作用。
Ther Adv Med Oncol. 2024 Jan 28;16:17588359231220511. doi: 10.1177/17588359231220511. eCollection 2024.
2
DNMT1/DNMT3a-mediated promoter hypermethylation and transcription activation of ICAM5 augments thyroid carcinoma progression.DNMT1/DNMT3a 介导的 ICAM5 启动子超甲基化和转录激活促进甲状腺癌进展。
Funct Integr Genomics. 2024 Jan 17;24(1):12. doi: 10.1007/s10142-024-01293-3.
3
Integrated molecular analysis reveals hypermethylation and overexpression of HOX genes to be poor prognosticators in isocitrate dehydrogenase mutant glioma.整合分子分析显示，HOX 基因的高甲基化和过表达是异柠檬酸脱氢酶突变型胶质瘤的不良预后标志物。
Neuro Oncol. 2023 Nov 2;25(11):2028-2041. doi: 10.1093/neuonc/noad126.
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The DNA methylation status of the TERT promoter differs between subtypes of mature B-cell lymphomas.端粒酶逆转录酶（TERT）启动子的DNA甲基化状态在成熟B细胞淋巴瘤的不同亚型之间存在差异。
Blood Cancer J. 2023 Jun 26;13(1):98. doi: 10.1038/s41408-023-00872-0.
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Prospects and feasibility of synergistic therapy with radiotherapy, immunotherapy, and DNA methyltransferase inhibitors in non-small cell lung cancer.放疗、免疫疗法和 DNA 甲基转移酶抑制剂联合治疗非小细胞肺癌的前景和可行性。
Front Immunol. 2023 Feb 17;14:1122352. doi: 10.3389/fimmu.2023.1122352. eCollection 2023.
6
The Molecular Interplay between Human Oncoviruses and Telomerase in Cancer Development.人类致癌病毒与端粒酶在癌症发展中的分子相互作用
Cancers (Basel). 2022 Oct 26;14(21):5257. doi: 10.3390/cancers14215257.
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Effect of Omega-3 Fatty Acids on Telomeres-Are They the Elixir of Youth?ω-3 脂肪酸对端粒的影响——它们是青春的灵药吗？
Nutrients. 2022 Sep 9;14(18):3723. doi: 10.3390/nu14183723.
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Tieing together loose ends: telomere instability in cancer and aging.系紧松散的末端：癌症和衰老中的端粒不稳定。
Mol Oncol. 2022 Sep;16(18):3380-3396. doi: 10.1002/1878-0261.13299. Epub 2022 Aug 16.
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Expression in Wilms Tumor Is Regulated by Promoter Mutation or Hypermethylation, WT1, and N-MYC.肾母细胞瘤中的表达受启动子突变或高甲基化、WT1和N-MYC调控。
Cancers (Basel). 2022 Mar 25;14(7):1655. doi: 10.3390/cancers14071655.
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DNA Methylation in Lung Cancer: Mechanisms and Associations with Histological Subtypes, Molecular Alterations, and Major Epidemiological Factors.肺癌中的DNA甲基化：机制及其与组织学亚型、分子改变和主要流行病学因素的关联
Cancers (Basel). 2022 Feb 15;14(4):961. doi: 10.3390/cancers14040961.

DNA hypermethylation within TERT promoter upregulates TERT expression in cancer.

作者信息

Lee Donghyun D, Leão Ricardo, Komosa Martin, Gallo Marco, Zhang Cindy H, Lipman Tatiana, Remke Marc, Heidari Abolfazl, Nunes Nuno Miguel, Apolónio Joana D, Price Aryeh J, De Mello Ramon Andrade, Dias João S, Huntsman David, Hermanns Thomas, Wild Peter J, Vanner Robert, Zadeh Gelareh, Karamchandani Jason, Das Sunit, Taylor Michael D, Hawkins Cynthia E, Wasserman Jonathan D, Figueiredo Arnaldo, Hamilton Robert J, Minden Mark D, Wani Khalida, Diplas Bill, Yan Hai, Aldape Kenneth, Akbari Mohammad R, Danesh Arnavaz, Pugh Trevor J, Dirks Peter B, Castelo-Branco Pedro, Tabori Uri

出版信息

J Clin Invest. 2019 Apr 1;129(4):1801. doi: 10.1172/JCI128527.

DOI:10.1172/JCI128527
PMID:30932912
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6436876/
Abstract
摘要